FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ph-p4
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General Information
Symbol
Dmel\ph-p4
Species
D. melanogaster
Name
FlyBase ID
FBal0039751
Feature type
allele
Associated gene
Dmel\ph-p
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
PM hybrid dysgenesis
(Saget and Randsholt, 1994, Dura et al., 1987)
Progenitor genotype
Caused by aberration
Df(1)ph4
Cytology
Description

Deletion of approximately 10kb that joins the 5' end (promoter, untranslated leader and 5' coding sequences) of ph-p to the 3' end of ph-d (3' coding region and untranslated sequences) and removes all sequences in between.

(Saget and Randsholt, 1994)

Deletion of some of ph-d and some of ph-p.

(Dura et al., 1987)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
X:2,128,823..2,130,069 [-]
Comment:

ph-p4 is a 10kb deletion that removes the 3' end of ph-p and the 5' end of ph-d. The breakpoint maps within a 1247bp region that is identicle between the two genes but cannot be further localized.

(Saget and Randsholt, 1994)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Hemizygous males usually have sex combs on the second and third legs, show a partial transformation of the posterior wing compartment towards the haltere and show a partial transformation of abdominal segment A4 towards A5, at both 25 and 29oC. Hemizygous males rarely show loss of the humerus and occasionally show partial transformation of abdominal segment A1 towards A2 at 25oC. At 29oC, both these phenotypes are more common. The expressivity and penetrance of these homeotic transformation phenotypes are comparable in ph-p2 and ph-p4 males.

      (Saget and Randsholt, 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      ph-p4 has phenotype, suppressible by ph-d+tSa

      (Saget and Randsholt, 1994)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Males are completely rescued by ph-d+tSa.

      (Saget and Randsholt, 1994)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ph-p4
      ph4
      (Saget and Randsholt, 1994)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)