FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\shiEM66
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General Information
Symbol
Dmel\shiEM66
Species
D. melanogaster
Name
FlyBase ID
FBal0039913
Feature type
allele
Associated gene
Dmel\shi
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Grant et al., 1998, Katzen and Bishop, 1996, Katzen, 1990)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G?A. Amino acid replacement: D189N. D189N is in the GTPase domain.

(Grant et al., 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:15,895,179..15,895,179 [+]
Nucleotide change:

G15895179A

Reported nucleotide change:

G616A

Amino acid change:

D189N | shi-PA; D189N | shi-PB; D189N | shi-PC; D189N | shi-PE; D189N | shi-PF; D189N | shi-PG; D189N | shi-PH; D189N | shi-PI; D189N | shi-PJ; D189N | shi-PK; D189N | shi-PL; D189N | shi-PM; D189N | shi-PN; D189N | shi-PO; D189N | shi-PP

Reported amino acid change:

D189N

(Grant et al., 1998)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygotes become paralysed within 2 minutes at a temperature of 37oC.

      (Grant et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      shi alleles show complex complementation patterns. Member of subgroup b of alleles.

      (Katzen, 1990)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      em66
      (Katzen and Bishop, 1996)
      shiEM66
      Name Synonyms
      Secondary FlyBase IDs
        References (3)