FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\tld+t12
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General Information
Symbol
Dmel\tld+t12
Species
D. melanogaster
Name
FlyBase ID
FBal0040017
Feature type
allele
Associated gene
Dmel\tld
Associated Insertion(s)
Carried in Construct
P{tld+12}
Key Links
Genomic Maps

Transgenic product class
genomic_DNA
(Shimell et al., 1991)
wild_type
(Shimell et al., 1991)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Shimell et al., 1991)
wild_type
(Shimell et al., 1991)
Mutagen
in vitro construct
(Saunders et al., 1997, Ferguson and Anderson, 1992, Shimell et al., 1991)
Progenitor genotype
Carried in construct
P{tld+12}
Cytology
Description

14kb SalI fragment containing the entire tld transcription unit and the 5' half of the asp transcription unit.

(Saunders et al., 1997)

12kb genomic fragment carrying tld, the 5' half of asp and 10kb of flanking DNA.

(Shimell et al., 1991)
Allele components
Component
Use(s)
Regulatory region(s)
tld
Encoded product / tool
tld
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
rescue_region
3R:24,744,184..24,757,649 [+]
Linked to:
SalI-EcoRI restriction fragment
Comment:

Position of restriction fragment on reference sequence inferred by FlyBase curator.

(Shimell et al., 1991)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      At the restrictive temperature of 29oC, maliMBT tldMBT yetiMBT spzMBT mutants show 100% lethality during the third larval instar. Third instar larvae have brain tumours of undifferentiated tissue. If these animals are rescued with tld+t12, they show 100% pupal lethality and hyperplastic brains at the restrictive temperature. At the restrictive temperature of 29oC, tldMBT yetiMBT mutants show 90% pupal lethality. The brain of third instar larvae is hyperplastic. If these animals are rescued with tld+t12, they show 30% pupal lethality and normal brains at the restrictive temperature. At the restrictive temperature of 29oC, tldMBT yetiMBT spzMBT mutants show 100% lethality during the third larval instar. Third instar larvae have brain tumours of undifferentiated tissue. If these animals are rescued with tld+t12, they show 60% pupal lethality and hyperplastic brains at the restrictive temperature.

      (Riede, 2001)

      Increased dose of tld+ does not suppress the dpp mutant phenotype.

      (Ferguson and Anderson, 1992)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      tld+t12
      Name Synonyms
      Secondary FlyBase IDs
        References (4)