FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\tldE6
Open Close
General Information
Symbol
Dmel\tldE6
Species
D. melanogaster
Name
FlyBase ID
FBal0040033
Feature type
allele
Associated gene
Dmel\tld
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Finelli et al., 1994)
Mutagen
ethyl methanesulfonate
(Finelli et al., 1994)
Progenitor genotype
Cytology
Description

Double mutant. Amino acid replacement: V21M. Amino acid 21 falls in the signal peptide domain of the tld protein. Amino acid replacement: D728N. Amino acid 728 falls in the C3 domain of the tld protein.

(Finelli et al., 1994)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:24,749,886..24,749,886 [+]
Nucleotide change:

G24749886A

Reported nucleotide change:

G?A

Amino acid change:

V31M | tld-PA

Reported amino acid change:

V21M

Comment:

Position of mutation on reference sequence inferred by FlyBase curator. Difference beteween actual and reported amino acid substitution due to authors using M11 as the start Met. One of two amino acid substitutions in this line.

(Finelli et al., 1994)
point_mutation
3R:24,752,372..24,752,372 [+]
Nucleotide change:

G24752372A

Reported nucleotide change:

G?A

Amino acid change:

D738N | tld-PA

Reported amino acid change:

D728N

Comment:

Position of mutation on reference sequence inferred by FlyBase curator. Difference beteween actual and reported amino acid substitution due to authors using M11 as the start Met. One of two mutations in this line.

(Finelli et al., 1994)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Weak ventralization.

      (Finelli et al., 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      tld alleles form an allelic series with respect to embryonic cuticle phenotype. Going from mildest phenotype to strongest: tldE4 = tldE6 = tldE8 < tldE5 = tldE10 = tldE14 = tld15 < tldE7 = tldE9 = tldE11.

      (Finelli et al., 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      tldE6
      Name Synonyms
      Secondary FlyBase IDs
        References (1)