FB2026_03 , released September 17, 2026
Allele: Dmel\tshhs.PdZ
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General Information
Symbol
Dmel\tshhs.PdZ
Species
D. melanogaster
Name
heat shock construct of de Zulueta
FlyBase ID
FBal0040054
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Progenitor genotype
Carried in construct
Cytology
Description

Entire coding region of a tsh cDNA expressed from an Hsp70 promoter.

Allele components
Component
Use(s)
Regulatory region(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Embryos heat shocked for 20 minutes at 37oC show trunk-type denticle belts in the head region, though the trunk and tail region are not affected. Embryos treated at the blastoderm stage show defects in head, truck and tail parts. Embryos treated later (stage 6 or later) do not show segmentation defects in a significant proportion of larvae. 38% of larvae treated at or before stage 10 show homeotic transformations of head to trunk identity, most strikingly in the labial segment, where naked cuticle, a prothoracic denticle belt and a T1 beard appear. Not all head structures are suppressed, as maxillary sense organs, cirri and mouth hooks remain. Longer heat shocks cause more extreme transformations of procephalon and maxillary segment occur, though transformation is still not as complete as for the labial segment. In combination with Scrhs.PG, tshhs.PdZ causes more extreme prothoracic transformations in procephalon and maxillary segment than tshhs.PdZ alone. tshhs.PdZ increases the expressivity of the homeotic transformations caused by Antphs.PHTA or Ubxhs.PG.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescues
Comments

Partially rescues null tsh8 or strong tsh9 phenotype.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
tshhs.PdZ
Name Synonyms
heat shock construct of de Zulueta
Secondary FlyBase IDs
    References (2)