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General Information
Symbol
Ecol\lacZE(spl)m8-HLH.2.61
Species
E. coli
Name
FlyBase ID
FBal0041188
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
E(spl)m8-lacZ, E(spl)m8 2.61-lacZ
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

2.612kb of 5' E(spl)m8-HLH promoter sequences, driving expression of lacZ from a minimal Hsp70 promoter.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
distribution deduced from reporter
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Information
Statement
Reference

Ecol\lacZE(spl)m8-HLH.2.61 drives expression in the outer optic anlage, with stronger expression near the medial transition zone where the medulla neuroblasts form.

E(spl)m8-HLH transcript is expressed in the inner and outer optic anlagen (IPC, OPC), most strongly in the medial epithelial cells of the OPC. Expression is also observed in medulla forming neuroblasts, and in newly generated medulla neurons and their axons.

In third instar imaginal discs, expression initially strong in regions undergoing PNS development; in the leg, these correspond to the chordotonal organs in the femur and tibia. Expression is observed near the presumptive joints of the leg; resolves in pupa into one-cell wide stripes proximal to the leg constrictions.

In third instar wing disc, pattern of expression described as 'resembling' that of E(spl).

In early embryo, expression differs slightly from that of E(spl) : expression in the mesectoderm anlagen is in a pair-rule pattern rather than continuous, and expression extends into the mesoderm anlagen rather than being restricted to the mesectoderm anlagen. In stage 9 embryos, expressed in a ladder-like pattern of cells in the ventral neurectoderm.

 
Marker for
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Product includes 9 amino acids from E(spl) protein.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Ecol\lacZE(spl).2.61
Ecol\lacZE(spl)m8-HLH.2.61
lacZE(spl).2.61
Name Synonyms
Secondary FlyBase IDs
    References (15)