FlyBase Allele Report: Dmel\osk[ΔBRE]

General Information

Symbol

Dmel\osk^ΔBRE

Species

D. melanogaster

Name

FlyBase ID

FBal0044232

Feature type

allele

Associated gene

Dmel\osk

Associated Insertion(s)

Carried in Construct

P{oskBRE^-}

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Kim-Ha et al., 1995)

Progenitor genotype

Carried in construct

P{oskBRE^-}

Cytology

Description

Construct: aret response elements (BRE) have been deleted from osk 3' UTR.

(Kim-Ha et al., 1995)

Allele components

Component

Use(s)

Encoded product / tool

osk

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic abdomen | ectopic

(Micklem et al., 2000)

embryonic head

(Micklem et al., 2000)

embryonic head, with osk⁶

(Kim-Ha et al., 1995)

prothoracic ventral denticle belt, with osk⁶

(Kim-Ha et al., 1995)

Detailed Description

Statement

Reference

24% of embryos derived from osk^A87/Df(3R)osk females carrying osk^ΔBRE have head defects, 49% show loss of thoracic and head segments and 21% are bicaudal.

(Reveal et al., 2010)

Addition of osk^ΔBRE to wild-type mothers, suppresses head development in about half of embryos laid, and causes a duplication of abdominal segments at the anterior (a bicaudal phenotype) in over a third.

(Micklem et al., 2000)

Most osk⁶ homozygotes carrying one copy of P{oskBRE^-} have anterior pattern deletions, head structures and the first thoracic denticle belt are missing, two copies cause a more severe posteriorization of the body pattern phenotype.

(Kim-Ha et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

osk^ΔBRE, stau² has ventral denticle belt phenotype, suppressible by stau^{ΔdRBD5.αTub67C.Tag:MYC}

(Micklem et al., 2000)

osk^ΔBRE, stau² has embryonic epidermis phenotype, suppressible by stau^{ΔdRBD5.αTub67C.Tag:MYC}

(Micklem et al., 2000)

osk^ΔBRE has embryonic abdomen phenotype, suppressible by stau²

(Micklem et al., 2000)

osk^ΔBRE has embryonic abdomen | ectopic phenotype, suppressible by stau²

(Micklem et al., 2000)

Other

Statement

Reference

osk^ΔBRE, stau² has abdominal ventral denticle belt phenotype

(Micklem et al., 2000)

osk^ΔBRE, stau² has embryonic abdomen phenotype

(Micklem et al., 2000)

osk^ΔBRE, stau^{ΔdRBD5.αTub67C.Tag:MYC} has abdominal ventral denticle belt phenotype

(Micklem et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

None of the embryos laid by stau², osk^ΔBRE mothers develop a bicaudal phenotype, and almost all form only one abdominal segment at the posterior. A third of embryos laid by stau^{Δloop2.αTub67C.T:Hsap\MYC}, stau², osk^ΔBRE mothers develop a bicaudal phenotype, another third show suppression of head development and partial or complete rescue of the abdomen. stau², osk^ΔBRE, stau^{ΔdRBD5.αTub67C.T:Hsap\MYC} mothers lay embryos with significantly more abdominal denticle belts than seen in stau²,osk^ΔBRE alone.

(Micklem et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to rescue

osk^ΔBRE fails to rescue osk⁶

(Kim-Ha et al., 1995)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

osk^ΔBRE

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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