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General Information
Symbol
Dmel\stau2
Species
D. melanogaster
Name
FlyBase ID
FBal0016165
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
stauD3, staufenD3
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Deletion of approximately 250bp, approximately 0.8kb from the site of the P{ry11}staury9 insertion.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Heterozygous stau2 flies show normal 1-d memory after spaced or massed training.

stau3/stau2 exhibit severe defects in one-day memory after spaced training when raised at 29oC, but are similar to wild-type at 18oC.

Ooplasmic streaming is normal at stage 9 and stage 10b in mutant oocytes.

In stau2 embryos the NB6-4T-derived are present in most glial cell, one cell is missing in the remaining cases.

Prevents the posterior accumulation of G-iα65A protein.

hts RNA localization proceeds normally in embryos derived from stau mutant mothers.

stau2;6xP{osk+108} embryos exhibit a class of embryos with abdominal deletions typical of posterior group mutations.

Homozygotes have strong abdominal defects. stau2/stau3 heterozygotes at 18oC have a weak abdominal defect, it is strong at 29oC.

Absence of posterior pole plasm, polar granules and pole cells.

Embryos laid by stau2 homozygous mothers form a bcd gradient in the anterior region of the embryo, this partial mislocalization leads to a shallower protein gradient.

Slight reduction of the anteriormost region and defects in abdomen development. bcd protein levels are 50% that of wild type embryos.

strong allele

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

stau2 has abnormal memory phenotype, enhanceable by Fmr13/Fmr1[+]

Enhancer of
Statement
Reference
Suppressor of
Statement
Reference
Other
Phenotype Manifest In
Enhanced by
Statement
Reference

stau2 has embryonic abdomen phenotype, enhanceable by nebMot

Suppressed by
Enhancer of
Statement
Reference
Suppressor of
Other
Additional Comments
Genetic Interactions
Statement
Reference

stau2/+ increase the penetrance of the posterior patterning phenotype of embryos derived from Ge-1Δ5 female germline clones from 4% to 32.8%.

Double heterozygous stau2/+; Fmr13/+ mutant flies show defective 1-d memory after spaced training, but not after massed training.

Embryos that express both miraαTub67C.T:Avic\GFP-m6 and stauΔdRBD5.αTub67C.T:Hsap\MYC in a stau2 background show the stauΔdRBD5.αTub67C.T:Hsap\MYC posterior group phenotype in which embryos develop a normal head and thorax, but lack the abdomen.

Embryos that express both miraΔ103.αTub67C.T:Avic\GFP-m6 and stauΔloop2.αTub67C.T:Hsap\MYC in a stau2 background lack a posterior abdomen and form an anterior abdomen with complete reverse polarity.

None of the embryos laid by stau2, oskΔBRE mothers develop a bicaudal phenotype, and almost all form only one abdominal segment at the posterior. stau2, oskΔBRE, stauΔdRBD5.αTub67C.T:Hsap\MYC mothers lay embryos with significantly more abdominal denticle belts than seen in stau2,oskΔBRE alone. A third of embryos laid by stauΔloop2.αTub67C.T:Hsap\MYC, stau2, oskΔBRE mothers develop a bicaudal phenotype, another third show suppression of head development and partial or complete rescue of the abdomen.

Maternal-effect bicaudal phenotype is enhanced if mothers are also mutant for nebMot.

Injection of nosN5 RNA into homozygous embryos completely rescues the abdominal phenotype.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Not rescued by
Comments

The addition of stauΔdRBD5.αTub67C.T:Hsap\MYC, or stauΔloop2.αTub67C.T:Hsap\MYC to stau2 mothers, produces embryos that show almost no rescue of the stau2 abdominal phenotype. The addition of stauΔN.αTub67C.T:Hsap\MYC, stau::Mdoa\stauDmMd.αTub67C.T:Hsap\MYC, or stauαTub67C.T:Hsap\MYC to stau2 mothers rescues the phenotypes seen in eggs laid by stau2 mothers.

100% of staudsRBD3mut, stau2 embryos die with head defects and no abdomen or pole cells.

Images (0)
Mutant
Wild-type
Stocks (5)
Notes on Origin
Discoverer
Comments
Comments

hb protein expression in early stau2 mutant embryos has been studied.

Strong allele of stau. Cytoplasmic transplantation of wild type plasm into the abdominal region restores normal abdominal development.

Although tud protein is present in mutant embryo extracts, its localization in the embryo is altered.

Transcripts from oskolc1 behave as those of the endogenous osk gene.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (67)