FB2026_02 , released June 18, 2026
Allele: Dmel\Arr12
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General Information
Symbol
Dmel\Arr12
Species
D. melanogaster
Name
FlyBase ID
FBal0044647
Feature type
allele
Associated gene
Dmel\Arr1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Dolph et al., 1993)

loss of function allele

(Satoh and Ready, 2005)
Mutagen
ethyl methanesulfonate
(Dolph et al., 1993)
Progenitor genotype
Cytology
Description

Nucleotide substitution: T1001A. Amino acid replacement: C154S.

(Dolph et al., 1993)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:18,079,266..18,079,266 [+]
Nucleotide change:

T18079266A

Amino acid change:

C154S | Arr1-PA; C154S | Arr1-PB; C140S | Arr1-PC

(Dolph et al., 1993)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      eye photoreceptor cell

      (Satoh and Ready, 2005)

      ommatidial cluster & endocytic vesicle

      (Satoh and Ready, 2005)
      Detailed Description
      Statement
      Reference

      In contrast to wild-type pupal photoreceptors, no ninaE-immunopositive large vesicles are seen following 1 hour light exposure in Arr12 mutants. Arr12 photoreceptors degenerate in 12L/12D and dark-raised adults.

      (Satoh and Ready, 2005)

      Arr12 heterozygotes show a decrease in electropalpogram amplitude in response to the odor of butanol or ethyl acetate, compared to a control strain. A similar phenotype is seen in Df(2L)II30/Arr12 flies. However, electroantennogram amplitudes in response to butanol or ethyl acetate are wild-type in Arr23 mutant flies.

      (Merrill et al., 2002)

      Whole cell voltage clamp recording of the light activated response of mutant photoreceptor cells show a wild type rate of deactivation (defined as the recovery of the photoresponse after termination of the stimulus).

      (Dolph et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      Arr12, Arr23 has abnormal smell perception phenotype

      (Merrill et al., 2002)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Electroantennogram amplitudes in response to butanol or ethyl acetate are signifacntly reduced compared in Arr23; Arr12 double mutants compared to a control strain. Single mutants for either of these genes have wild-type responses.

      (Merrill et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Arr12
      arr12
      (Satoh and Ready, 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)