FB2026_02 , released June 18, 2026
Allele: Dmel\Arr21
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General Information
Symbol
Dmel\Arr21
Species
D. melanogaster
Name
FlyBase ID
FBal0044649
Feature type
allele
Associated gene
Dmel\Arr2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Dolph et al., 1993)
Progenitor genotype
Cytology
Description

Amino acid replacement: K356term.

(Dolph et al., 1993)

Nucleotide substitution: A1273T.

(Dolph et al., 1993)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:8,647,631..8,647,631 [-]
Nucleotide change:

A8647631T

Reported nucleotide change:

A1273T

Amino acid change:

K356term | Arr2-PA

Reported amino acid change:

K356term

(Dolph et al., 1993)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Arr21 is an enhancer of ommatidium phenotype of Gαq1, rdgC306

      (Kiselev et al., 2000)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Gα49B1, Arr21 animals raised in normal light show normal ommatidial structure. The addition of rdgC306 show a rapid degeneration of photoreceptor cells. The addition of Arr23 to rdgC306, Gα49B1 flies enhances the Deep Pseudopupil seen in these flies.

      (Kiselev et al., 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      Flash-response in dissociated ommatidia from Arr21 flies are essentially wildtype in both Ca[2+] and Ca[2+]-free solutions.

      (Liu et al., 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Arr21
      (Shieh et al., 2014, Kristaponyte et al., 2012)
      arr21
      (Liu et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)