FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Calreth-as311
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General Information
Symbol
Dmel\Calreth-as311
Species
D. melanogaster
Name
FlyBase ID
FBal0044708
Feature type
allele
Associated gene
Dmel\Calr
Associated Insertion(s)
P{}Calreth-as311
Carried in Construct
Also Known As
ethas311
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gamo et al., 1998, Dodo et al., 1995)
Progenitor genotype
Associated Insertion(s)
P{}Calreth-as311
Cytology
Description

Insertion of a modified P-element 26bp upstream of the Crc initiation codon.

(Gamo et al., 1998)

5.7-kb P-element insertion.

(Dodo et al., 1995)

P-element insertion 29 bases upstream of the initiation codon.

(Dodo et al., 1995)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant flies are hypersensitive to diethylether anesthesia but resistant to isoflurane anesthesia compared to wild type. Mutant flies show normal sensitivity to halothane anesthesia.

      (Gamo et al., 2003)

      Homozygotes are sensitive to ether (lower concentrations are required for anaesthesia compared to wild-type flies).

      (Gamo et al., 1998)

      Ether sensitive.

      (Dodo et al., 1995)

      Hypersensitive to ether anesthesia.

      (Dodo et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Calreth-as311 is rescued by Calrhs.PG

      (Gamo et al., 2003)
      Comments

      The hypersensitivity to diethylether anesthesia and resistance to isoflurane anesthesia which is seen in Crceth-as311 flies is rescued by expression of Crchs.PG under the control of heat shock.

      (Gamo et al., 2003)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Excision of the P-element results in a response to ether that is almost the same as wild type.

      (Gamo et al., 1998)

      Excision of the inserted P-element reverts the mutant phenotypes of hypersensitivity to diethylether anesthesia and resistance to isoflurane anesthesia.

      (Gamo et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Calreth-as311
      Crceth-as311
      ethas311
      (Dodo et al., 1995)
      ethas311
      (Gamo et al., 2003, Gamo et al., 1998, Dodo et al., 1995)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)