FB2026_02 , released June 18, 2026
Allele: Dmel\Met2
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General Information
Symbol
Dmel\Met2
Species
D. melanogaster
Name
FlyBase ID
FBal0045043
Feature type
allele
Associated gene
Dmel\Met
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ashok et al., 1998, Minkoff and Wilson, 1992, Shemshedini and Wilson, 1990, Wilson and Fabian, 1986)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q401term.

(Wilson et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:11,618,068..11,618,068 [+]
Nucleotide change:

C11618068T

Amino acid change:

Q401term | Met-PA; Q401term | Met-PB

Reported amino acid change:

Q401term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Wilson et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes show increased resistance to methoprene compared to controls.

      Homozygous females have a reduced rate of oviposition compared to controls.

      16% of mutant flies have a small number of defective ommatidia in the posterior quarter of the eye.

      (Wilson et al., 2006)

      Flies carrying Rst(1)JH2 have a competitive disadvantage compared to wild-type flies.

      (Minkoff and Wilson, 1992)

      Rst(1)JH1 mutants are 6 times more resistant than wild-type to S31183 (2-1-methyl-2-(4-phenoxyphenoxy)-ethoxy-pyridine), a juvenile hormone mimic, in a white puparial assay and about 20 times more resistant than wild-type to S31183 in a larval feeding assay.

      (Riddiford and Ashburner, 1991)

      Moderate allele. Only minor differences in penetration, excretion, sequestration and metabolism of juvenile hormone III are detected in Rst(1)JH2 flies compared to Rst(1)JH+ flies. Rst(1)JH2 flies have an approximately 5-fold lower binding affinity for juvenile hormone III than Rst(1)JH+ flies.

      (Shemshedini and Wilson, 1990)

      Homozygotes are resistant to methoprene, although less strong than Rst(1)JH1. Also resistant to methoprene induced morphogenetic abnormalities and tumours. Heterozygous males are susceptible to methoprene. Rst(1)JH1/Rst(1)JH2 transheterozygotes are more resistant to methoprene than Rst(1)JH2 homozygotes.

      (Wilson and Fabian, 1986)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      The fitness component(s) responsible for the competitive disadvantage of flies carrying mutant alleles of Rst(1)JH have been analysed in Rst(1)JH1, Rst(1)JH2, Rst(1)JH3, Rst(1)JHD29 and Rst(1)JHN6 flies. Small but significant differences were found between the pooled Rst(1)JH alleles and wild-type for pupal developmental time, pupal mortality, and early adult fecundity. These differences results in a large competitive disadvantage.

      (Minkoff and Wilson, 1992)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Met2
      (Wilson and Fabian, 1986)
      Met2
      (Wilson et al., 2006, Beno et al., 2005, Ashok et al., 1998, Riddiford and Ashburner, 1991, Shemshedini and Wilson, 1990)
      Rst(1)JH2
      Name Synonyms
      Secondary FlyBase IDs
        References (7)