FB2026_02 , released June 18, 2026
Allele: Dmel\Wnt280
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General Information
Symbol
Dmel\Wnt280
Species
D. melanogaster
Name
FlyBase ID
FBal0045291
Feature type
allele
Associated gene
Dmel\Wnt2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Kozopas et al., 1998)
Mutagen
ethyl methanesulfonate
(Kozopas et al., 1998, Kozopas, 1996.4.29, Kozopas et al., 1996)
Progenitor genotype
Cytology
Description

Amino acid replacement: W265term.

(Kozopas et al., 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:9,502,774..9,502,774 [+]
Nucleotide change:

G9502774A

Amino acid change:

W265term | Wnt2-PA; W238term | Wnt2-PB

Reported amino acid change:

W265term

Comment:

G to A nucleotide change at the second or third position of the wild type Trp codon leads to a nonsense mutation (exact site of mutation unspecified). The mutation was annotated at the second base of the codon.

(Kozopas et al., 1998)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      With variable penetrance, homozygous males have much smaller testes than wild-type. The hub cells, cyst cells and terminal epithelial cells are present. The germ cell lineage is also present. The outermost pigment layer, which normally covers both the testis and seminal vesicles, is absent. The muscle cell layer of the testis sheath is malformed or incomplete. Testis colour: the testis sheath lacks yellow pigmentation. Homozygotes have held out wings.

      (Kozopas et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Wnt280
      Wnt2EMS80
      (Llimargas and Lawrence, 2001)
      Wnt2ems80
      Name Synonyms
      Secondary FlyBase IDs
        References (4)