FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\capu2F
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General Information
Symbol
Dmel\capu2F
Species
D. melanogaster
Name
FlyBase ID
FBal0045434
Feature type
allele
Associated gene
Dmel\capu
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: P596T.

    (Emmons et al., 1995)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    2L:3,874,354..3,874,354 [-]
    Nucleotide change:

    C3874354A

    Amino acid change:

    P597T | capu-PA; P587T | capu-PB; P745T | capu-PD; P818T | capu-PE; P899T | capu-PF; P470T | capu-PG; P645T | capu-PH; P836T | capu-PI; P627T | capu-PJ

    Reported amino acid change:

    P596T|FBrf0083891

    Comment:

    Site of nucleic acid difference inferred by FlyBase curator based on reported amino acid change; CDS from reference sequence longer by 1 amino acid from published CDS in GB:U34258 and thus the mutation coordinates differ by 1

    (Emmons et al., 1995)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        The actin mesh (a uniform network of actin filaments present throughout the cytoplasm) that is seen in wild-type stage 9 oocytes is much weaker than normal in mutant oocytes at this stage.

        (Dahlgaard et al., 2007)

        Less than 5% of embryos laid by homozygous females have abnormal eggshells. Abnormal microtubule distribution in stage 8 and 9 egg chambers (distribution resembles that of stage 10 egg chambers), long and thick tubulin fibres are seen wrapping around the cortex of mutant oocytes. Egg chambers undergo premature microtubule based cytoplasmic streaming.

        (Emmons et al., 1995)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Enhancer of
        Statement
        Reference

        capu2F is an enhancer of phenotype of chic01320

        (Manseau et al., 1996)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        6% of the eggs from capu2/capu2F and 30% from chic01320/chic01320 have fused dorsal appendages, whereas 76% of those from capu2, chic01320/capu2F, chic01320 have dorsal/ventral defects. Similarly capu2F, chic01320/capu2F, chic01320 produce 70% eggs with dorsal/ventral defects while capu2F/capu2F alone produced only 2%.

        (Manseau et al., 1996)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Weak capu allele.

        (Emmons et al., 1995)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        capu2F
        (Dahlgaard et al., 2007)
        Name Synonyms
        Secondary FlyBase IDs
          References (4)