FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\elavDmORF
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General Information
Symbol
Dmel\elavDmORF
Species
D. melanogaster
Name
FlyBase ID
FBal0045583
Feature type
allele
Associated gene
Dmel\elav
Associated Insertion(s)
Carried in Construct
P{elavDmORF}
Key Links
Transgenic product class
genomic_DNA
(Yao and White, 1991)
wild_type
(Yao and White, 1991)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Yao and White, 1991)
wild_type
(Yao and White, 1991)
Mutagen
in vitro construct
(Samson, 1998, Koushika et al., 1996, Yao and White, 1991)
Progenitor genotype
Carried in construct
P{elavDmORF}
Cytology
Description

Genomic DNA covering 7.5kb of the elav locus, including the ORF, fused to 800bp of αTub84B trailer sequences.

(Yao and White, 1991)
Allele components
Component
Use(s)
Regulatory region(s)
elav
Encoded product / tool
elav
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      A single copy of elavDmORF has no deleterious effect on flies. The viability of flies carrying two copies of elavDmORF is very reduced and any escapers are sterile.

      (Samson, 1998)

      Provides 72% rescue of lethality of elav5.

      (Yao and White, 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      elavDmORF rescues elav5/elavts1

      (Haussmann et al., 2008)

      elavDmORF rescues elav5

      (Lisbin et al., 2000)

      elavDmORF rescues elavts1

      (Lisbin et al., 2000)

      elavDmORF rescues elav5

      (Samson, 1998)

      elavDmORF rescues elav5

      (Koushika et al., 1996)
      Partially rescues

      elavDmORF partially rescues elav1

      (Yannoni and White, 1999)

      elavDmORF partially rescues elav5

      (Yannoni and White, 1999)

      elavDmORF partially rescues elavts1

      (Yannoni and White, 1999)
      Comments

      elavts1/elav5 animals eclose as adults when they are rescued by elavDmORF (providing that embryogenesis occurs at the permissive temperature for the elavts1 allele).

      The reduction in bouton number at the neuromuscular junction which is seen in elavts1/elav5 animals reared at the restrictive temperature during larval life is rescued by elavDmORF.

      (Haussmann et al., 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      elavDMORF
      (Yannoni and White, 1999)
      elavDmORF
      Name Synonyms
      Secondary FlyBase IDs
        References (9)