FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\Fkbp59k00424
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General Information
Symbol
Dmel\Fkbp59k00424
Species
D. melanogaster
Name
FlyBase ID
FBal0046051
Feature type
allele
Associated gene
Dmel\Fkbp59
Associated Insertion(s)
P{lacW}Fkbp59k00424
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Prokopenko et al., 2000, Kania et al., 1995)
Progenitor genotype
Associated Insertion(s)
P{lacW}Fkbp59k00424
Cytology
Description

P{lacW} insertion in the 5' UTR, 21bp upstream of the FKBP59 AUG codon.

(Prokopenko et al., 2000)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
AF175915
AF175916
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The average number of crystal cells per embryo is reduced in homozygous stage 13-14 embryos compared to wild type.

      (Milchanowski et al., 2004)

      Homozygous embryos exhibit slight organisation defects in the dorsal cluster, abnormally positioned lateral chordotonal (Lch) neurons and occasional fasciculation defects.

      (Kania et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Separable from: P{lacW}Rya-r44Fk00424b. It is not clear whether the organisational defects seen in the PNS in the "l(2)k00424" line are due to the P{lacW}Rya-r44Fk00424b insertion in Rya-r44F at 44F or the P{lacW}FKBP59k00424 insertion in FKBP59 at 30D.

      (Prokopenko et al., 2000)
      Comments
      Comments

      Complements: l(2)0632006320. Complements: FKBP59k08408. Complements: FKBP59k09010. Complements: l(2)k12408k12408. Complements: l(2)k14204k14204.

      (BDGP Project Members, 1994-1999)

      Lethality not revertible with excision of the P{lacW} insert.

      (Kania et al., 1995)
      External Crossreferences and Linkouts ( 2 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (7)
      Reported As
      Symbol Synonym
      4/24
      (Kania et al., 1995)
      FKBP59K00424
      (Milchanowski et al., 2004)
      FKBP59k00424
      Fkbp59k00424
      l(2)k00424
      (Prokopenko et al., 2000)
      l(2)k004244-24
      l(2)k00424k00424
      (BDGP Project Members, 1994-1999)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)