FB2026_02 , released June 18, 2026
Allele: Dmel\ninaES95F
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General Information
Symbol
Dmel\ninaES95F
Species
D. melanogaster
Name
FlyBase ID
FBal0046183
Feature type
allele
Associated gene
Dmel\ninaE
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Colley et al., 1995, Kurada and O'Tousa, 1995)
Progenitor genotype
Cytology
Description

Amino acid replacement: S95F. Nucleotide substitution: C455T.

(Colley et al., 1995)

Amino acid replacement: S95F.

(Kurada and O'Tousa, 1995)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:19,887,684..19,887,684 [-]
Nucleotide change:

C19887684T

Amino acid change:

S95F | ninaE-PA

Reported amino acid change:

S95F|FBrf0080181

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Kurada and O'Tousa, 1995)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  retinitis pigmentosa
      CEA
      (Colley et al., 1995)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Severe retinal degradation.

      (Colley et al., 1995)

      ERG recordings demonstrate homozygotes and heterozygotes lack the prolonged depolarising afterpotential (PDA). Heterozygotes lose the deep pseudopupil by 21 days of age, transheterozygotes with ninaED1 retain the pseudopupil structure for much longer. Light enhances the rate of retinal degeneration in heterozygotes.

      (Kurada and O'Tousa, 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      ninaES95F is a suppressor of phenotype of norpAP24

      (Kurada and O'Tousa, 1995)

      ninaES95F is a suppressor of phenotype of rdgC306

      (Kurada and O'Tousa, 1995)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The heterozygous genotype does not prevent the accumulation of endoplasmic reticulum (ER) present in ninaA2 flies.

      (Kurada and O'Tousa, 1995)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      S95F
      (Bentrop, 1998)
      ninaES95F
      Name Synonyms
      Secondary FlyBase IDs
        References (3)