FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\oskM139L
Open Close
General Information
Symbol
Dmel\oskM139L
Species
D. melanogaster
Name
FlyBase ID
FBal0046233
Feature type
allele
Associated gene
Dmel\osk
Associated Insertion(s)
Carried in Construct
P{oskM139L}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Breitwieser et al., 1996, Markussen et al., 1995)
Progenitor genotype
osk+t6.45
(Markussen et al., 1995)
Carried in construct
P{oskM139L}
Cytology
Description

Mutation in the second start codon.

(Breitwieser et al., 1996)

Construct: Nucleotide substitution: A626C. Amino acid replacement: M139L.

(Markussen et al., 1995)
Allele components
Component
Use(s)
Regulatory region(s)
osk
Encoded product / tool
osk
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      oskM139L; osk1/Df(3R)p-XT103 embryos express only the long osk isoform. These embryos show patterning defects and a "twisted phenotype". Muscle development is defective with embryos showing a dramatic reduction in the number of muscles, a large number of unfused myoblasts and defects in muscle morphology.

      (Beckett and Baylies, 2006)

      No embryos expressing oskM139L in a oskA87/Df(3R)p-XT103 background hatch. 100% of these embryos have posterior cuticle defects. 84-91% of embryos expressing both oskM1R and oskM139L in a oskA87/Df(3R)p-XT103 background hatch. The unhatched embryos develop cuticles without obvious patterning defects. 100% of females derived from the embryos that hatch have wild-type ovaries.

      (Vanzo and Ephrussi, 2002)

      osk1/Df(3R)p-XT103 embryos carrying P{oskM139L} do not hatch, embryos typically develop 2 to 4 abdominal segments. The few adults that emerge are sterile.

      (Markussen et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Produces only long osk protein.

      (Breitwieser et al., 1996)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      oskM139L
      (Hurd et al., 2016, Morais-de-Sá et al., 2013, Beckett and Baylies, 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)