FlyBase Allele Report: Dmel\osk[187]

General Information

Symbol

Dmel\osk¹⁸⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0193624

Feature type

allele

Associated gene

Dmel\osk

Associated Insertion(s)

I{}osk¹⁸⁷

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

I{}osk¹⁸⁷

Cytology

Description

Contains an I-element in the regulatory region upstream of the osk gene.

(Jenny et al., 2006)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile (with Df(3R)p-XT103)

(Jenny et al., 2006)

Phenotype Manifest In

embryonic abdomen, with osk^mM1mM2

(Jenny et al., 2006)

embryonic abdomen, with osk^mM1SLmM2

(Jenny et al., 2006)

embryonic abdomen (with osk¹)

(Jenny et al., 2006)

embryonic abdomen (with osk²)

(Jenny et al., 2006)

embryonic abdomen (with osk⁹)

(Jenny et al., 2006)

germline cell (with osk¹)

(Jenny et al., 2006)

germline cell (with osk²)

(Jenny et al., 2006)

germline cell (with osk⁹)

(Jenny et al., 2006)

Detailed Description

Statement

Reference

osk¹/osk¹⁸⁷, osk⁹/osk¹⁸⁷ and osk²/osk¹⁸⁷ transheterozygous embryos lack an abdomen and germline.

osk¹⁸⁷/Df(3R)p-XT103 females fail to lay eggs although oocytes are determined and begin to develop, but then arrest.

osk¹⁸⁷/Df(3R)p-XT103 females that carry either the osk^mM1mM2 or the osk^mM1SLmM2 transgene are able to lay eggs but the resulting embryos lack abdomens.

(Jenny et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Other

Statement

Reference

osk[+]/osk¹⁸⁷, pAbp^37-2 has embryo phenotype

(Vazquez-Pianzola et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Females double heterozygous for pAbp^37-2 and osk¹⁸⁷ produce much more frequently embryos with strong posterior phenotypes than females heterozygous for each of these mutations alone.

(Vazquez-Pianzola et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

osk²

(Jenny et al., 2006)

osk¹

(Jenny et al., 2006)

osk⁹

(Jenny et al., 2006)

Rescued by

osk¹⁸⁷/Df(3R)p-XT103 is rescued by osk^+t6.45

(Jenny et al., 2006)

osk¹⁸⁷/Df(3R)p-XT103 is rescued by osk^M1L

(Jenny et al., 2006)

osk¹⁸⁷/Df(3R)p-XT103 is rescued by osk^M139L

(Jenny et al., 2006)

Partially rescued by

osk¹⁸⁷/Df(3R)p-XT103 is partially rescued by osk^mM1mM2

(Jenny et al., 2006)

osk¹⁸⁷/Df(3R)p-XT103 is partially rescued by osk^mM1SLmM2

(Jenny et al., 2006)

Comments

Expression of the either the osk^mM1mM2 or the osk^mM1SLmM2 transgene rescues the egg-less phenotype of osk¹⁸⁷/Df(3R)p-XT103 females but the embryos produced lack an abdomen.

(Jenny et al., 2006)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Mutagen comment: this allele was discovered in a P-element mutagenesis screen, although it was found to have an I-element insertion.

(Jenny et al., 2006)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

osk¹⁸⁷

(Vazquez-Pianzola et al., 2011, Jenny et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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