FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\oskmM1SLmM2
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General Information
Symbol
Dmel\oskmM1SLmM2
Species
D. melanogaster
Name
FlyBase ID
FBal0193626
Feature type
allele
Associated gene
Dmel\osk
Associated Insertion(s)
Carried in Construct
P{oskmM1SLmM2}
Key Links
Transgenic product class
frameshift_variant
(Jenny et al., 2006)
start_lost
(Jenny et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
frameshift_variant
(Jenny et al., 2006)
start_lost
(Jenny et al., 2006)
Mutagen
in vitro construct
(Jenny et al., 2006)
Progenitor genotype
oskmM1mM2
(Jenny et al., 2006)
Carried in construct
P{oskmM1SLmM2}
Cytology
Description

A sequence predicted to adopt a stable hairpin structure has been inserted between the two mutated initiation codons and a frame-shift (CCACTGG instead of CCACCTGG) has been introduced downstream of the second initiation codon. The hairpin structure has been introduced to prevent translation from in-frame methionine codons downstream.

(Jenny et al., 2006)
Allele components
Component
Use(s)
Encoded product / tool
osk
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Both osk187/Df(3R)p-XT103 and oskA87/Df(3R)p-XT103 females that carry either the oskmM1SLmM2 transgene are able to lay eggs but the resulting embryos lack abdomens.

      (Jenny et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      oskmM1SLmM2 partially rescues oskA87/Df(3R)p-XT103

      (Jenny et al., 2006)

      oskmM1SLmM2 partially rescues osk187/Df(3R)p-XT103

      (Jenny et al., 2006)
      Comments

      Expression of the oskmM1SLmM2 transgene rescues the egg-less phenotype of oskA87/Df(3R)p-XT103 and osk187/Df(3R)p-XT103 females but the embryos produced lack an abdomen.

      (Jenny et al., 2006)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      oskmM1SLmM2
      Name Synonyms
      Secondary FlyBase IDs
        References (1)