FlyBase Allele Report: Dmel\osk[9]

General Information

Symbol

Dmel\osk⁹

Species

D. melanogaster

Name

FlyBase ID

FBal0013311

Feature type

allele

Associated gene

Dmel\osk

Associated Insertion(s)

Carried in Construct

Also Known As

osk³⁴⁶

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Nucleotide substitution: C1641T.

(Kim-Ha et al., 1991)

Amino acid replacement: Q324term.

(Kim-Ha et al., 1991)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:8,936,458..8,936,458 [+]

Nucleotide change:

C8936458T

Reported nucleotide change:

C1641T

Amino acid change:

Q324term | osk-PA; Q186term | osk-PC

Reported amino acid change:

Q324term

(Kim-Ha et al., 1991)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile | maternal effect

(Hay et al., 1990)

lethal | maternal effect | recessive

(Ephrussi et al., 1991, Lehmann and Nusslein-Volhard, 1991)

male sterile | maternal effect

(Hay et al., 1990)

Phenotype Manifest In

embryonic/first instar larval cuticle (with osk¹)

(Zimyanin et al., 2007)

embryonic/first instar larval cuticle (with osk⁶)

(Yoshida et al., 2004)

embryonic abdomen (with osk⁶)

(Yoshida et al., 2004)

embryonic abdomen (with osk¹⁸⁷)

(Jenny et al., 2006)

embryonic abdomen (with osk^A87)

(Jenny et al., 2006)

germline cell (with osk¹⁸⁷)

(Jenny et al., 2006)

germline cell (with osk^A87)

(Jenny et al., 2006)

pole granule

(Lehmann and Nusslein-Volhard, 1991)

pole plasm

(Lehmann and Nusslein-Volhard, 1991)

primordial germ cell

(Lehmann and Nusslein-Volhard, 1991)

ventral denticle belt (with osk¹)

(Zimyanin et al., 2007)

Detailed Description

Statement

Reference

Embryos from osk⁹/osk¹ mothers have a typical posterior group phenotype with 0-4 denticle belts.

(Zimyanin et al., 2007)

Embryos from osk⁹/osk⁶ mothers completely lack an abdomen.

(Yoshida et al., 2004)

Lack posterior body pattern elements and germ cells.

(Kim-Ha et al., 1991)

Absence of posterior pole plasm, polar granules and pole cells.

(Lehmann and Nusslein-Volhard, 1991)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

osk⁶/osk⁹ has embryonic abdomen phenotype, non-enhanceable | maternal effect by Pka-R1¹⁸³⁰⁴/Df(3L)ME107

(Yoshida et al., 2004)

osk⁶/osk⁹ has embryonic/first instar larval cuticle phenotype, non-enhanceable | maternal effect by Pka-R1¹⁸³⁰⁴/Df(3L)ME107

(Yoshida et al., 2004)

NOT suppressed by

Statement

Reference

osk⁶/osk⁹ has embryonic/first instar larval cuticle phenotype, non-suppressible | maternal effect by Pka-R1¹⁸³⁰⁴/Df(3L)ME107

(Yoshida et al., 2004)

osk⁶/osk⁹ has embryonic abdomen phenotype, non-suppressible | maternal effect by Pka-R1¹⁸³⁰⁴/Df(3L)ME107

(Yoshida et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

The phenotype of embryos from osk⁹/osk⁶ mothers is unaffected by the mothers carrying Pka-R1¹⁸³⁰⁴/Df(3L)ME107.

(Yoshida et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

osk¹⁸⁷

(Jenny et al., 2006)

osk^A87

(Jenny et al., 2006)

Not rescued by

osk⁹/osk¹ is not rescued by osk^stop.UASp

(Zimyanin et al., 2007)

Comments

Maternal osk^{stop.Scer\UAS.P\T} + Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} fails to rescue the posterior group phenotype seen in cuticles of embryos laid by osk⁹/osk¹ mothers.

(Zimyanin et al., 2007)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Abnormal localization of osk mRNA.

(Kim-Ha et al., 1991)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

osk³⁴⁶

(Rangan et al., 2009, Zimyanin et al., 2007, Zimyanin et al., 2007, Jenny et al., 2006, Cinnamon et al., 2004, Yoshida et al., 2004, Markussen et al., 1995, Clark et al., 1994, St. Johnston, 1993, Ephrussi et al., 1991, Kim-Ha et al., 1991, Lehmann and Nusslein-Volhard, 1991, St. Johnston et al., 1991, Zhang et al., 1991, Hay et al., 1990, Tearle and Nusslein-Volhard, 1987)

osk⁹

Name Synonyms

Secondary FlyBase IDs

References (16)

Report Sections

Open Close