FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\scrtjo11
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General Information
Symbol
Dmel\scrtjo11
Species
D. melanogaster
Name
FlyBase ID
FBal0046413
Feature type
allele
Associated gene
Dmel\scrt
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Roark et al., 1995)
Mutagen
Delta2-3 transposase
(Roark et al., 1995)
Progenitor genotype
P{lacW}D6-3-3
(Roark et al., 1995)
Cytology
Description

Deletion removing all of scrt coding region represented in the longest scrt cDNA.

(Roark et al., 1995)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes show low viability, though they do eclose as adults under favourable conditions and are fertile in outcrosses. Subtle but 100% penetrant rough eye phenotype. In superficial sections of the eye the pattern of lenses and interommatidial bristles is relatively normal. In deeper sections ommatidia show fewer than 7 photoreceptors, and the photoreceptors are shrunken relative to wild type. Numbers of pigment cells is reduced and ommatidial units are broken and abnormally spaced. Eyes frequently show scratched facets near to the edge. Wings are held vertically under mild anesthesia and the flies are so weak and uncoordinated that they often get stuck in the food immediately after eclosion. Homozygous embryos appear morphologically normal.

      (Roark et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Other
      Statement
      Reference

      dpn1, scrtjo11 has lethal | recessive phenotype

      (Roark et al., 1995)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Whereas either single mutant shows escapers, dpn1, scrtjo11 double mutant embryos never hatch and exhibit a dramatic reduction of both central and peripheral nervous system nervous system. dpn1/+,scrtjo11 have an enhanced rough eye phenotype and more severe loss of photoreceptors than for scrtjo11 alone.

      (Roark et al., 1995)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Complements scy1.

      (Roark et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      scrtj011
      (Wang et al., 2024)
      scrtjo11
      (Wang et al., 2024, Ramat et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)