FB2026_02 , released June 18, 2026
Allele: Dmel\spis.MtnA
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General Information
Symbol
Dmel\spis.MtnA
Species
D. melanogaster
Name
secreted
FlyBase ID
FBal0046515
Feature type
allele
Associated gene
Dmel\spi
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
in vitro construct
(Gabay et al., 1997, Schweitzer et al., 1995)
Progenitor genotype
Cytology
Description

Construct: Amino acid replacement: K129. Encodes a secreted spi product. The truncated spi@ product is expressed from a metallothionein promoter.

(Schweitzer et al., 1995)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Can trigger Egfr, in an S2 cell assay.

      (Schweitzer et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Activation of Egfr signalling by secreted spi is studied in S2-Egfr-expressing cells exposed to secreted spi.

      (Schnepp et al., 1998)

      Transfected into S2R+ and Kc167 cells and used in a screen for receptor tyrosine kinase/ERK regulators.

      (Friedman and Perrimon, 2006)

      Carried in plasmid "Mtsspi" and assayed in Schneider S2 cells.

      (Schweitzer et al., 1995)

      Carried in plasmid "sSpitz" and assayed in Schneider S2 cells.

      (Schweitzer et al., 1995)

      Carried in plasmid "Mtspi" and assayed in Schneider S2 cells to test the ability of Egfr and spi to induce argos transcription.

      (Golembo et al., 1996)

      Schneider S2 cells expressing Egfr have been incubated with secreted spi protein produced using spis.MtnA.

      (Gabay et al., 1997)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      spis.MtnA
      Name Synonyms
      secreted
      (Schweitzer et al., 1995, Schweitzer et al., 1995)
      Secondary FlyBase IDs
        References (6)