FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\tra2unspecified
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General Information
Symbol
Dmel\tra2unspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0046612
Feature type
allele
Associated gene
Dmel\tra2
Associated Insertion(s)
Carried in Construct
Also Known As
unspecified
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    (FlyBase Curators, 2025-)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Chromosomal females (XX) homozygous for tra2unspecified are transformed into "pseudomales". They are sterile even in the presence of a Y chromosome. The gonads form testes which are generally non-gametogenic, containing degenerated germ cells and debris or gonial cells whose sex cannot be determined. A variable proportion are gametogenic, containing either oogenic or spermatogenic stages of germ cell development (never both in the same gonad). In these cases oogenesis is arrested anywhere between stages S3 and S10A, and spermatogenesis is frequently arrested at the spermatocyte stage, although some later stages of spermatogenic differentiation are seen.

        (Nothiger et al., 1989)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhancer of
        Statement
        Reference

        tra2[+]/tra2unspecified is an enhancer of abnormal sex-determination | dominant | female phenotype of dsxD

        (Nothiger et al., 1987)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        tra2unspecified dsxD XX double heterozygotes are more masculinised than dsxD heterozygotes.

        (Nothiger et al., 1987)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        tra2unspecified is rescued by tra2+t3.9

        (Goralski et al., 1989)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        tra2unspecified
        unspecified
        (Amrein and Axel, 1997, Nothiger et al., 1987)
        Name Synonyms
        Secondary FlyBase IDs
          References (8)