FB2026_02 , released June 18, 2026
Allele: Dmel\wupAhdp-5
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General Information
Symbol
Dmel\wupAhdp-5
Species
D. melanogaster
Name
FlyBase ID
FBal0046816
Feature type
allele
Associated gene
Dmel\wupA
Associated Insertion(s)
Carried in Construct
Also Known As
hdp5
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Deak et al., 1982)
Progenitor genotype
Cytology
Description

Nucleotide substitution: AG to AA at the 3' AG splice site at the intron preceding exon 6b1.

(Nongthomba et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:18,109,571..18,109,571 [-]
Nucleotide change:

G18109571A

Reported nucleotide change:

G?A

Comment:

AG to AA mutation at the 3' acceptor site in the intron preceding exon 6b1.

(Nongthomba et al., 2004)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In flight muscles of recently eclosed adults myofibrils are missing. Thick and thin filaments are present in the sarcoplasm though normal Z discs are not evident.

      (Beall and Fyrberg, 1991)

      Heterozygotes are flightless with a normal wing posture. Homozygotes are flightless with an abnormal wing posture. Most double heterozygotes with upint-3, up101 or upx have an abnormal wing posture.

      (Homyk and Emerson, 1988)

      Flies are flightless and hold their wings in an abnormal position, and sometimes show variable jump ability. DVMs and DLMs are scant and TDTs are reduced. Myofibrillar structure is highly disorganized.

      (Deak et al., 1982)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      wupAhdp-5 has indirect flight muscle cell phenotype, non-suppressible by Tm2D53

      (Naimi et al., 2001)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Z disc morphology is improved in the double mutant with Mhc7. Thin filaments are reduced, even in the absence of myosin.

      (Beall and Fyrberg, 1991)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      hdp5
      (Nongthomba et al., 2004, Naimi et al., 2001, Homyk and Emerson, 1988, Deak et al., 1982)
      heldup5
      (Beall and Fyrberg, 1991)
      wupAhdp-5
      Name Synonyms
      Secondary FlyBase IDs
        References (5)