FB2026_03 , released September 17, 2026
Allele: Dmel\Gαq1.Q203L
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General Information
Symbol
Dmel\Gαq1.Q203L
Species
D. melanogaster
Name
FlyBase ID
FBal0048753
Feature type
allele
Associated gene
Dmel\Gαq
Associated Insertion(s)
Carried in Construct
P{DGq1-203}
Key Links
Transgenic product class
missense_variant
(Lee et al., 1994)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Lee et al., 1994)
Mutagen
in vitro construct
(Lee et al., 1994)
Progenitor genotype
Gαqm1
(Lee et al., 1994)
Carried in construct
P{DGq1-203}
Cytology
Description

Construct: Amino acid replacement: Q203L.

(Lee et al., 1994)
Allele components
Component
Use(s)
Regulatory region(s)
Gαq
Encoded product / tool
Gαq
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Electrophysiological studies of the retina reveal the light intensity required to elicit a response was greater for P{DGq1-203} flies than wild type. Both the initiation and termination responses are significantly different. ERG recordings demonstrate mutants are less sensitive to light and do not reach the same maximal response amplitude as wild type flies, even after prolonged dark adaptation. rdgB9; P{DGq1-203} lines show signs of degeneration, small irregular rhabdomeres and holes in the retina. Retinas of norpA36; rdgB2 mutants fail to degenerate in the dark or light, rdgB2; P{DGq1-203} retinas degenerate in the dark and norpA36; rdgB2; P{DGq1-203} triple mutant retinas fail to degenerate in the light or dark.

      (Lee et al., 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Heads exhibit a small GTPase activity in the dark.

      (Lee et al., 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Gα49B1.Q203L
      Gαq1.Q203L
      Name Synonyms
      Secondary FlyBase IDs
        References (1)