FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\abclu2
Open Close
General Information
Symbol
Dmel\abclu2
Species
D. melanogaster
Name
FlyBase ID
FBal0049278
Feature type
allele
Associated gene
Dmel\ab
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Hu et al., 1995)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C?T. Amino acid replacement: R585C. Mutation occurs in the region encoding the second ZF.

(Hu et al., 1995)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:11,258,382..11,258,382 [+]
Nucleotide change:

C11258382T

Amino acid change:

R585C | ab-PA; R575C | ab-PB; R575C | ab-PD; R575C | ab-PF

Comment:

The amino acid position of the mutation is reported with respect to ab-PA.

(Hu et al., 1995)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      larval abdominal segmental nerve

      (Hu et al., 1995)

      larval transverse nerve

      (Hu et al., 1995)

      muscle cell of abdominal 2 dorsal acute muscle 3

      (Hu et al., 1995)

      muscle cell of abdominal 2 dorsal oblique muscle 3

      (Hu et al., 1995)

      muscle cell of abdominal 2 dorsal oblique muscle 5

      (Hu et al., 1995)

      muscle cell of abdominal 2 lateral oblique muscle 1

      (Hu et al., 1995)

      muscle cell of abdominal 3 dorsal acute muscle 3

      (Hu et al., 1995)

      muscle cell of abdominal 3 dorsal oblique muscle 3

      (Hu et al., 1995)

      muscle cell of abdominal 3 dorsal oblique muscle 5

      (Hu et al., 1995)

      muscle cell of abdominal 3 lateral oblique muscle 1

      (Hu et al., 1995)

      muscle cell of abdominal 4 dorsal acute muscle 3

      (Hu et al., 1995)

      muscle cell of abdominal 4 dorsal oblique muscle 3

      (Hu et al., 1995)

      muscle cell of abdominal 4 dorsal oblique muscle 5

      (Hu et al., 1995)

      muscle cell of abdominal 4 lateral oblique muscle 1

      (Hu et al., 1995)

      muscle cell of abdominal 5 dorsal acute muscle 3

      (Hu et al., 1995)

      muscle cell of abdominal 5 dorsal oblique muscle 3

      (Hu et al., 1995)

      muscle cell of abdominal 5 dorsal oblique muscle 5

      (Hu et al., 1995)

      muscle cell of abdominal 5 lateral oblique muscle 1

      (Hu et al., 1995)

      muscle cell of abdominal 6 dorsal acute muscle 3

      (Hu et al., 1995)

      muscle cell of abdominal 6 dorsal oblique muscle 3

      (Hu et al., 1995)

      muscle cell of abdominal 6 dorsal oblique muscle 5

      (Hu et al., 1995)

      muscle cell of abdominal 6 lateral oblique muscle 1

      (Hu et al., 1995)

      muscle cell of abdominal 7 dorsal acute muscle 3

      (Hu et al., 1995)

      muscle cell of abdominal 7 dorsal oblique muscle 3

      (Hu et al., 1995)

      muscle cell of abdominal 7 dorsal oblique muscle 5

      (Hu et al., 1995)

      muscle cell of abdominal 7 lateral oblique muscle 1

      (Hu et al., 1995)
      Detailed Description
      Statement
      Reference

      Severe wing venation defect when heterozygous with ab94. During embryogenesis the SNb axons pause at the edge of muscle 13 and form abnormal branches, instead of forming their wild type axonal extensions onto the muscle fibers. These aberrant branches wander over the prospective target muscles and occasionally form connections at ectopic sites. Mutants do not establish the three branched terminal arbor on muscles 7, 6, 13 and 12. The transverse nerve is often incomplete and invades the ventral muscle field. A few muscles (3, 5, 11, 20) show variably penetrant defects in their attachment to the epidermis, and variable defects in the location of their attachments.

      (Hu et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      abclu2
      Name Synonyms
      Secondary FlyBase IDs
        References (1)