FlyBase Allele Report: Dmel\aly[2]

General Information

Symbol

Dmel\aly²

Species

D. melanogaster

Name

FlyBase ID

FBal0049283

Feature type

allele

Associated gene

Dmel\aly

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(White-Cooper et al., 2000, Lin et al., 1996)

Progenitor genotype

Cytology

Description

Nucleotide substitution: C1475T.

(White-Cooper et al., 2000)

Amino acid replacement: Q414term.

(White-Cooper et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:3,024,957..3,024,957 [-]

Nucleotide change:

C3024957T

Reported nucleotide change:

C1475T

Amino acid change:

Q448term | aly-PA; Q448term | aly-PB

Reported amino acid change:

Q414term

(White-Cooper et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal meiotic cell cycle | adult stage (with aly^5p)

(Lu and Fuller, 2015)

abnormal meiotic cell cycle | recessive

(Lin et al., 1996)

male sterile (with aly³)

(Lin et al., 1996)

male sterile | recessive

(Lin et al., 1996)

viable (with aly³)

(Lin et al., 1996)

Phenotype Manifest In

nuclear lamina | adult stage | male (with aly⁵)

(Trost et al., 2016)

nucleolus | adult stage (with aly^5p)

(Lu and Fuller, 2015)

spermatocyte

(Lin et al., 1996)

spermatocyte (with aly³)

(Lin et al., 1996)

spermatocyte | adult stage (with aly^5p)

(Lu and Fuller, 2015)

testis

(Lin et al., 1996)

testis (with aly³)

(Lin et al., 1996)

Detailed Description

Statement

Reference

aly²/aly⁵ adult heterozygote males show morphological defects of the nuclear lamina in stage S4-S6 spermatocytes (the lamina has distinctly more ballon-like shape, lacking the deformations that correlate with chromosome distribution seen in wild-type), while in stage S3 the lamina is of wild-type appearance.

(Trost et al., 2016)

aly²/aly^5p mutant spermatocytes arrest at the G2/M transition of meiosis I, exhibit lobe-like extensions of the nucleolus, and the condensing autosomal bivalents largely remain as incompletely condensed crescents near the nuclear periphery.

(Lu and Fuller, 2015)

Sister chromatid separation occurs normally in homozygous mutants.

(Vazquez et al., 2002)

Early stages of spermatogenesis up through mature primary spermatocytes are present and normal. Postmeiotic stages are completely absent. Mutant testes have an abundance of mature primary spermatocytes with large, round nuclei and prominent nucleoli. Spermatocytes arrest in the G₂/M transition of meiosis I with partial chromosome condensation.

(Lin et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

aly²

(Berry et al., 2022, Fingerhut et al., 2019, Duan and Geyer, 2018, Trost et al., 2016, Lu and Fuller, 2015)

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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