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General Information
Symbol
Dmel\aly5
Species
D. melanogaster
Name
FlyBase ID
FBal0049286
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion of hobo into aly transcription unit, with a 10bp duplication of base pairs 1179-1188 (which lie within the open reading frame, region of amino acids 315-317).

Insertion components
H{}aly5
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

aly2/aly5 adult heterozygote males show morphological defects of the nuclear lamina in stage S4-S6 spermatocytes (the lamina has distinctly more ballon-like shape, lacking the deformations that correlate with chromosome distribution seen in wild-type), while in stage S3 the lamina is of wild-type appearance.

Nucleolar organisation is altered in aly5 mutant testes cells.

Chromosomes in mutant primary spermatocytes are apposed to the nuclear envelope (as occurs in wild-type primary spermatocytes), but they are fuzzier and less well defined than in wild type.

Early stages of spermatogenesis up through mature primary spermatocytes are present and normal. Postmeiotic stages are completely absent. Mutant testes have an abundance of mature primary spermatocytes with large, round nuclei and prominent nucleoli. Spermatocytes arrest in the G2/M transition of meiosis I with partial chromosome condensation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Morphologically, aly5 mutants expressing wucdsRNA.Scer\UAS under the control of Scer\GAL4bam.T:Hsim\VP16 are indistinguishable from single mutant testes. Nucleolar disorganisation, as found in aly5 mutants, is unaffected by expression of wucdsRNA.Scer\UAS.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
References (13)