FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\araDFM1
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General Information
Symbol
Dmel\araDFM1
Species
D. melanogaster
Name
FlyBase ID
FBal0049305
Feature type
allele
Associated gene
Dmel\ara
Associated Insertion(s)
Carried in Construct
Also Known As
iroDFM1
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Gomez-Skarmeta et al., 1996)
Mutagen
P-element activity
(Gomez-Skarmeta et al., 1996)
Delta2-3 transposase
(Leyns et al., 1996)
Progenitor genotype
ararF209
(Gomez-Skarmeta et al., 1996, Leyns et al., 1996)
Caused by aberration
Df(3L)iro-DFM1
Cytology
Description

Distal breakpoint maps between the second and third exon.

(Kehl et al., 1998)

Deficiency breakpoint maps to an intron in the protein coding region of the ara transcription unit (at the ararF209 insertion site).

(Gomez-Skarmeta et al., 1996)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      When homozygous, in wing clones, differentiation of L5 and the alula fail. Dorsal clones remove L5 dorsally, and ventral clones remove L5 ventrally. No other site in the wing showed a requirement for ara-caup. Notum cells lacking ara and caup are inviable.

      (Gomez-Skarmeta et al., 1996)

      araDFM1/ara1 flies have a strong iroquois phenotype. araDFM1/Df(3L)iro-2 flies die as embryos.

      (Leyns et al., 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      Df(3L)iro-DFM3, araDFM1 has visible phenotype

      (Pichaud and Casares, 2000)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Homozygous caupDFM1 somatic clones (containing the alleles caupDFM1 and araDFM1) in the abdomen are normal, except for lateral ones. The clones found in the lateral domains of the tergite are often depigmented; usually not all parts of the clones are affected to the same extent. These clones tend to be roundish.

      (Calleja et al., 2000)

      Homozygous Df(3L)iro-DFM1 (containing araDFM1 and removing caup) clones cause a series of phenotypes, adding progressively more 'ventral-type' tissue in the following order: dorsal eye overgrowth or ectopic dorsal eyes, overgrowth of ventral type of cuticle (ptilinum and rostral membrane) ectopic antennal pouches, antenna and maxillary palps. The extra head structures are produced autonomously, but the eyes can be composed of both mutant and wild-type ommatidia. The ectopic ventral structures, all grow from the orbital region of the head. The rest of the dorsal head is displaced by the over-grown tissue.

      (Pichaud and Casares, 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Phenotype may be less extreme than for araDFM3 because of the ectopic expression of a gene related to those of the Iroquois complex.

      (Gomez-Skarmeta et al., 1996)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      araDFM1
      iroDFM1
      (Gomez-Skarmeta et al., 1996, Leyns et al., 1996)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)