Con-positive longitudinal fascicles and commissures are abnormal in enC embryos. The muscles are grossly abnormal.
Fails to complement the adult phenotype of en1. Homozygous mutant embryos frequently hatch and show segment fusions varying from pair-wise fusions to milder fusions in which one or two denticle belts are partially fused.
Mutant embryos have some normal denticle belts, particularly in the anterior part of the embryo, but fused denticle belts with loss of naked cuticle are seen in approximately 50% of segments. The overall morphology of the central and peripheral nervous systems is slightly disrupted. The development of the NB 7-3 lineage is abnormal and only approximately 20% of the expected number of ventral ganglion serotonin-expressing neurons are seen in the mutant embryos.