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General Information
Symbol
Dmel\enC
Species
D. melanogaster
Name
FlyBase ID
FBal0049457
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Deletes en transcription unit, approximate coordinates -12 to -14 of the inv-en region. The deletion removes the entire P{en-lacZ(Xho)} as well as 36 upstream base pairs and extends through the first exon and to within 3bp of the splice acceptor of the first intron. The homeodomain-encoding section of the gene is not deleted.

Deficiency that removes from -300 relative to the en RNA start site to the end of en intron 1.

Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Con-positive longitudinal fascicles and commissures are abnormal in enC embryos. The muscles are grossly abnormal.

Fails to complement the adult phenotype of en1. Homozygous mutant embryos frequently hatch and show segment fusions varying from pair-wise fusions to milder fusions in which one or two denticle belts are partially fused.

Mutant embryos have some normal denticle belts, particularly in the anterior part of the embryo, but fused denticle belts with loss of naked cuticle are seen in approximately 50% of segments. The overall morphology of the central and peripheral nervous systems is slightly disrupted. The development of the NB 7-3 lineage is abnormal and only approximately 20% of the expected number of ventral ganglion serotonin-expressing neurons are seen in the mutant embryos.

Transheterozygotes with Df(3L)X37 and Df(3L)10H produce normal flies, transheterozygotes with Df(3L)E13 or Df(3R)slo8 produce flies with abnormal wings.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement
Reference
Phenotype Manifest In
Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

100% of ph-p410/Y; enC/+ double heterozygotes have a gap in the fourth wing vein at 25oC.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (5)