FlyBase Allele Report: Dmel\enc[R1]

General Information

Symbol

Dmel\enc^R1

Species

D. melanogaster

Name

FlyBase ID

FBal0049474

Feature type

allele

Associated gene

Dmel\enc

Associated Insertion(s)

Carried in Construct

Also Known As

encore^R1

Key Links

Allele class

heat sensitive gain of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

heat sensitive gain of function allele

(Hawkins et al., 1996)

Mutagen

ethyl methanesulfonate

(Hawkins et al., 1997, Hawkins et al., 1996)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle | recessive | heat sensitive

(Hawkins et al., 1996)

Phenotype Manifest In

dorsal appendage

(Hawkins et al., 1997)

dorsal appendage (with enc⁷⁹¹)

(Blumenstiel et al., 2009)

egg chamber

(Hawkins et al., 1996)

nurse cell

(Hawkins et al., 1996)

Detailed Description

Statement

Reference

Embryos derived from enc⁷⁹¹/enc^R1 females raised at 18[o]C have a fused dorsal appendage phenotype.

(Blumenstiel et al., 2009)

enc^R1/enc^Q4 mutant males progress through spermatogenesis normally, and no evidence of extra transit amplification of germline cysts prior to differentiation is observed.

(Insco et al., 2009)

Eggs derived from hemizygous females show a cold-sensitive ventralised egg-shell phenotype. More than 95% of the ventralised eggs have a single dorsal appendage at 18^oC.

(Hawkins et al., 1997)

Egg chambers exhibit doubling of the number of nurse cells, or in a small number of cases the egg chambers are bipolar or have less than 15 nurse cells. Phenotype is more severe at 25^oC. bam^Δ86 enc^R1 double mutants exhibit tumorous egg chambers, identical to the bam^Δ86 homozygous phenotype.

(Hawkins et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

enc⁷⁹¹

(Blumenstiel et al., 2009)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

108053

enc^R1 st¹ e¹ ca¹/TM3, Ser¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

enc^R1

(Insco et al., 2009, Insco et al., 2009)

enc^RI

(Ohlmeyer and Schupbach, 2003)

encore^R1

(Blumenstiel et al., 2009)

Name Synonyms

encoreR1

(Li et al., 2009)

Secondary FlyBase IDs

References (7)

Report Sections

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