FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Gad1unspecified
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General Information
Symbol
Dmel\Gad1unspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0049820
Feature type
allele
Associated gene
Dmel\Gad1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    (FlyBase Curators, 2025-)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Homozygous Gad1 mutant embryos removed manually from the egg are, like the few larvae that hatch, severely unco-odinated and contract their entire body in response to touch rather than initiating typical peristaltic "crawling" movements. Gross morphology of mutants is completely normal, with no defects visible. Muscle shape, patterning, and innervation are normal the gut and segmental patterning of the epidermis and denticle belts appear normal, and the central nervous system appears normally formed. At 22-24 hours after egg laying, trachea are inflated.

        (Featherstone et al., 2000)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Eighteen alleles have been isolated.

        (Harrison et al., 1995)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        Gad1unspecified
        l(3)64Anunspecified
        unspecified
        (Harrison et al., 1995)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)