FB2026_02 , released June 18, 2026
Allele: Dmel\tkvBrk25D1
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General Information
Symbol
Dmel\tkvBrk25D1
Species
D. melanogaster
Name
FlyBase ID
FBal0051068
Feature type
allele
Associated gene
Dmel\tkv
Associated Insertion(s)
Carried in Construct
P{tkvBrk25D1}
Key Links
Transgenic product class
genomic_DNA
(Morimura et al., 1996)
wild_type
(Morimura et al., 1996)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Morimura et al., 1996)
wild_type
(Morimura et al., 1996)
Mutagen
in vitro construct
(Morimura et al., 1996)
Progenitor genotype
Carried in construct
P{tkvBrk25D1}
Cytology
Description

Entire genomic region of Brk25D1 which encodes tkv.

(Morimura et al., 1996)
Allele components
Component
Use(s)
Regulatory region(s)
tkv
Encoded product / tool
tkv
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      P{tkvBrk25D1} has suboptimal levels of expression sufficient to rescue the lethality of tkv7/Df(2L)tkv2 through embryonic and larval development. Rescued adults display defects in the wing (cleft in the notum and reduction/deletion of the scutellum) and leg (duplication of ventral structures and loss of dorsal and distal structures) patterning.

      (Morimura et al., 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      tkvBrk25D1 rescues tkv5

      (Kim et al., 1996)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Q1A-8
      (Kim et al., 1996)
      tkvBrk25D1
      Name Synonyms
      Secondary FlyBase IDs
        References (2)