FlyBase Allele Report: Dmel\Jra[S82A.T92A.T107A.hs.sev]

General Information

Symbol

Dmel\Jra^{S82A.T92A.T107A.hs.sev}

Species

D. melanogaster

Name

FlyBase ID

FBal0052261

Feature type

allele

Associated gene

Dmel\Jra

Associated Insertion(s)

Carried in Construct

P{sE-D-jun^{S82A,T92A,T107A}}

Key Links

Transgenic product class

missense_variant

(Peverali et al., 1996)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Peverali et al., 1996)

Mutagen

in vitro construct

(Peverali et al., 1996)

Progenitor genotype

Carried in construct

P{sE-D-jun^{S82A,T92A,T107A}}

Cytology

Description

An Hsp70 promoter and a tandem duplication of the sev enhancer (sE) element drive expression of a mutated form of Jra that carries the amino acid substitutions S82A, T92A and T107A.

(Peverali et al., 1996)

Allele components

Component

Use(s)

Regulatory region(s)

Hsp70

sev

Encoded product / tool

Jra

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

photoreceptor cell R1

(Peverali et al., 1996)

photoreceptor cell R2

(Peverali et al., 1996)

photoreceptor cell R3

(Peverali et al., 1996)

photoreceptor cell R4

(Peverali et al., 1996)

photoreceptor cell R5

(Peverali et al., 1996)

photoreceptor cell R6

(Peverali et al., 1996)

photoreceptor cell R7

(Peverali et al., 1996)

Detailed Description

Statement

Reference

Mild effect on eye development, ommatidia lack outer photoreceptors or R7 cells.

(Peverali et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

Jra^{S82A.T92A.T107A.hs.sev} is a suppressor of photoreceptor cell R7 | ectopic phenotype of Ras85D^V12.sev

(Peverali et al., 1996)

Jra^{S82A.T92A.T107A.hs.sev} is a suppressor of phenotype of rl^10a

(Peverali et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Behaves as a dominant negative form of Jra.

(Peverali et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Jra^{S82A.T92A.T107A.hs.sev}

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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