FlyBase Allele Report: Dmel\E2f1[hs.PA]

General Information

Symbol

Dmel\E2f1^hs.PA

Species

D. melanogaster

Name

heat shock construct of Asano

FlyBase ID

FBal0052447

Feature type

allele

Associated gene

Dmel\E2f1

Associated Insertion(s)

Carried in Construct

P{hsp70-E2F}

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Asano et al., 1996)

Progenitor genotype

Carried in construct

P{hsp70-E2F}

Cytology

Description

Expression of a 3.8kb EcoRI-ApaI fragment of E2f1 cDNA is directed by an Hsp70 promoter.

(Asano et al., 1996)

Allele components

Component

Use(s)

Regulatory region(s)

Hsp70

Encoded product / tool

E2f1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Asano et al., 1996)

Phenotype Manifest In

interommatidial bristle

(Asano et al., 1996)

ommatidium

(Asano et al., 1996)

Detailed Description

Statement

Reference

Larvae do not survive a 30 minute heat shock. Rare adult escapers exhibit irregular ommatidial rows, fused ommatidia and duplicated interommatidial bristles.

(Asano et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

E2f1^hs.PA is a suppressor of embryonic/larval salivary gland | embryonic stage phenotype of Cdk1^UAS.cHa, CycA^UAS.cHa, Scer\GAL4^l(1)BP-1

(Hayashi and Yamaguchi, 1999)

Additional Comments

Genetic Interactions

Statement

Reference

The inhibition of endoreplication in the salivary gland caused by coexpression of both CycA^Scer\UAS.cHa and cdc2^Scer\UAS.cHa under the control of Scer\GAL4^l(1)BP-1 is reversed if the larvae are also expressing E2f^hs.PA.

(Hayashi and Yamaguchi, 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

E2f1^hs.PA

E2f^hs.PA

Name Synonyms

heat shock construct of Asano

(Asano et al., 1996)

Secondary FlyBase IDs

References (3)

Report Sections

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