FlyBase Allele Report: Dmel\Cf2[s.hs]

General Information

Symbol

Dmel\Cf2^s.hs

Species

D. melanogaster

Name

sense

FlyBase ID

FBal0055189

Feature type

allele

Associated gene

Dmel\Cf2

Associated Insertion(s)

Carried in Construct

P{CF2-s}

Key Links

Transgenic product class

cDNA

(Hsu et al., 1996)

wild_type

(Hsu et al., 1996)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Hsu et al., 1996)

wild_type

(Hsu et al., 1996)

Mutagen

in vitro construct

(Hsu et al., 1996)

Progenitor genotype

Carried in construct

P{CF2-s}

Cytology

Description

2kb EagI-ClaI fragment of the ovarian Cf2 cDNA containing 119bp of 5' UTR, entire coding region and 429bp 3'UTR is cloned in the forward orientation downstream of the Hsp70 promoter.

(Hsu et al., 1996)

Allele components

Component

Use(s)

Regulatory region(s)

Hsp70

Encoded product / tool

Cf2

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | non-rescuable maternal effect

(Hsu et al., 2001)

some die during embryonic stage | non-rescuable maternal effect

(Hsu et al., 2001)

Phenotype Manifest In

dorsal appendage

(Hsu et al., 1996)

dorsal appendage | non-rescuable maternal effect

(Hsu et al., 2001)

egg chamber

(Hsu et al., 1996)

embryonic/first instar larval cuticle | non-rescuable maternal effect

(Hsu et al., 2001)

follicle cell

(Hsu et al., 1996)

ventral denticle belt | non-rescuable maternal effect

(Hsu et al., 2001)

Detailed Description

Statement

Reference

Females expressing Cf2^s.hs using heat shocks produce eggs with either narrowed and fused dorsal appendages or no appendages at all. Embryos produced these females mated to wild-type males show cuticle patterning defects; expanded and fused ventral denticles.

(Hsu et al., 2001)

Overexpression of P{CF2-s} causes moderate ventralisation of egg chambers; egg chambers become elongated in shape, dorsal appendages fuse and shrink and the number of main body follicle cells increases.

(Hsu et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

Cf2^s.hs is a suppressor of egg chamber phenotype of fs(1)K10¹

(Hsu et al., 1996)

Cf2^s.hs is a suppressor of egg chamber phenotype of spir¹

(Hsu et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

Overexpression of Cf2^s.hs in fs(1)K10¹ mutants can reduce the dorsalising effects, 10% of eggs display two distinct dorsal appendages. Overexpression during oogenesis similarly rescues the maternal dorsalising effect so 12% of embryos have restored ventral denticles.

(Hsu et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Cf2^s.hs

Name Synonyms

sense

(Hsu et al., 1996)

Secondary FlyBase IDs

References (3)

Report Sections

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