FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\htlZZ81
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General Information
Symbol
Dmel\htlZZ81
Species
D. melanogaster
Name
FlyBase ID
FBal0057257
Feature type
allele
Associated gene
Dmel\htl
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Gisselbrecht et al., 1996)
Progenitor genotype
Cytology
Description

Deletion of 187bp (nucleotides 1901 to 2087, FBrf0058097) at the 3' end of the coding sequence and insertion of 2 novel nucleotides introducing a frameshift and 11 novel amino acids followed by a premature stop codon.

(Gisselbrecht et al., 1996)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3R:18,045,898..18,046,084 [-]
Comment:

Deletion of 187bp (nucleotides 1901 to 2087 in FBrf0058097) at the 3' end of the coding sequence and insertion of 2 novel nucleotides, resulting in a frameshift, which introduces 11 novel amino acids followed by a premature stop codon.

(Gisselbrecht et al., 1996)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      htlZZ81 has mesoderm phenotype, suppressible by Scer\GAL4twi.PG/Ras85DG13Q.UAS

      (Gisselbrecht et al., 1996)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Scer\GAL4twi.PG mediated expression of Ras85DG13Q.Scer\UAS allows partial rescue of the mesodermal migration defect, partial induction of the proper dorsolateral migration of the mesoderm.

      (Gisselbrecht et al., 1996)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      htlZZ81
      htlzz81
      (Ayoub et al., 2023, Dorfman et al., 2002)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)