FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\htlDN.UAS
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General Information
Symbol
Dmel\htlDN.UAS
Species
D. melanogaster
Name
Dominant Negative
FlyBase ID
FBal0057261
Feature type
allele
Associated gene
Dmel\htl
Associated Insertion(s)
Carried in Construct
P{DN-htl}
Also Known As
UAS-htlDN
Key Links
Transgenic product class
dominant_negative_variant
(Beiman et al., 1996)
inframe_deletion
(Beiman et al., 1996)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Beiman et al., 1996)
inframe_deletion
(Beiman et al., 1996)
Mutagen
in vitro construct
(Beiman et al., 1996)
Progenitor genotype
Carried in construct
P{DN-htl}
Cytology
Description

UASt regulatory sequences drive expression of a dominant-negative form of htl (encodes the normal extracellular and transmembrane domains, but lacks the cytoplasmic kinase domain.

(Beiman et al., 1996)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
htl
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of htlDN.Scer\UAS in the lateral glia, under the control of Scer\GAL4158, inhibits the embryonic condensation of the ventral nerve cord.

      (Olofsson and Page, 2005)

      When expression is driven by Scer\GAL4twi.PB the number of HVM cells is reduced.

      (San Martin and Bate, 2001)

      Scer\GAL4hs.PB-mediated expression 4-5 hours after egg laying causes some muscles to be missing.

      (Yarnitzky et al., 1997)

      Scer\GAL4hs.2sev mediated expression at 2.5 hours AEL does not lead to defects in mesoderm spreading, but causes the formation irregular patches of visceral mesoderm that fail to fuse. Expression induced at 5 hours AEL causes irregular patterns of cardial cells. Expression induced at 4 hours AEL causes missing ventral muscles or misdirected muscles.

      (Beiman et al., 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      htlDN.Scer\UAS
      htlDN.UAS
      Name Synonyms
      Dominant Negative
      (Beiman et al., 1996)
      Secondary FlyBase IDs
        References (6)