FlyBase Allele Report: Dmel\fra[2]

General Information

Symbol

Dmel\fra²

Species

D. melanogaster

Name

FlyBase ID

FBal0057435

Feature type

allele

Associated gene

Dmel\fra

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Kolodziej et al., 1996)

Mutagen

Progenitor genotype

Cytology

Description

Deletion of the N terminal portion of fra. Deletion extends 3' beyond the fra gene.

(Kolodziej et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

fra²/fra[+] is an enhancer of abnormal neuroanatomy | recessive phenotype of N^l1N-ts1

(Kuzina et al., 2011)

Other

Statement

Reference

Df(2R)en-SFX31, fra² has abnormal neuroanatomy phenotype

(Joly et al., 2007)

Df(2R)en-SFX31, fra² has lethal | adult stage phenotype

(Joly et al., 2007)

Phenotype Manifest In

Enhancer of

Statement

Reference

fra²/fra[+] is an enhancer of pioneer neuron phenotype of N^l1N-ts1

(Kuzina et al., 2011)

Other

Statement

Reference

Df(2R)en-SFX31, fra² has larval ventral nerve cord phenotype

(Joly et al., 2007)

Df(2R)en-SFX31, fra² has larval anterior commissure phenotype

(Joly et al., 2007)

Df(2R)en-SFX31, fra² has larval posterior commissure phenotype

(Joly et al., 2007)

Df(2R)en-SFX31, fra² has lateral tract phenotype

(Joly et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

The N^l1N-ts1 pioneer axon phenotype is strongly enhanced by heterozygosity for fra².

(Kuzina et al., 2011)

Approximately 67% of fra²/Df(2R)en-SFX31 double mutants exhibit defects in axonal pathfinding. Stage 15 embryos display dramatic defects in ventral nerve cord architecture, with the posterior commissures missing or fused with the anterior commissures, and longitudinal tracts thinner. Nearly all the segments are affected in these embryos.

(Joly et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

fra²

(Kuzina et al., 2011, Joly et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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