FlyBase Allele Report: Dmel\Egfr[WT.hs]

General Information

Symbol

Dmel\Egfr^WT.hs

Species

D. melanogaster

Name

FlyBase ID

FBal0058984

Feature type

allele

Associated gene

Dmel\Egfr

Associated Insertion(s)

Carried in Construct

P{hs-Egfr.wt}

Key Links

Transgenic product class

wild_type

(Wides et al., 1990)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Wides et al., 1990)

Mutagen

in vitro construct

(Wides et al., 1990)

Progenitor genotype

Carried in construct

P{hs-Egfr.wt}

Cytology

Description

Contains a type II Egfr cDNA (containing the distal alternative 5' exon) encoding the four exons from the 5' end of the Egfr gene fused to a genomic Egfr fragment encoding the 3' large exon and 3' non-coding sequences. This construct is expressed under the control of an Hsp70 promoter.

(Wides et al., 1990)

Allele components

Component

Use(s)

Regulatory region(s)

Hsp70

Encoded product / tool

Egfr

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Egfr^WT.hs, vap^KS67 has lethal phenotype

(Botella et al., 2003)

Phenotype Manifest In

Enhancer of

Statement

Reference

Egfr^WT.hs is an enhancer of adult optic lobe | adult stage phenotype of vap²

(Botella et al., 2003)

Suppressor of

Statement

Reference

Egfr^WT.hs is a suppressor of wing vein phenotype of aos^hs.PF

(Schweitzer et al., 1995)

Additional Comments

Genetic Interactions

Statement

Reference

Egfr^WT.hs is lethal in a vap^KS67 homozygous background.

(Botella et al., 2003)

Egfr^WT.hs/+ suppresses the wing-vein loss phenotype of argos^hs.PF/+ animals heat-shocked at 34^oC.

(Schweitzer et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Carried in a plasmid, transfected into S2 cells and used in immunoprecipitation assays.

(Spencer and Cagan, 2003)

Carried in plasmid "pDER", transfected into Schneider 2 cells and used in autophosphorylation assays.

(Wides et al., 1990)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Egfr^WT.hs

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

Open Close