FlyBase Allele Report: Dmel\Cat[tOa]

General Information

Symbol

Dmel\Cat^tOa

Species

D. melanogaster

Name

FlyBase ID

FBal0059197

Feature type

allele

Associated gene

Dmel\Cat

Associated Insertion(s)

Carried in Construct

P{Cat7.0}

Key Links

Transgenic product class

genomic_DNA

(Orr and Sohal, 1992)

wild_type

(Orr and Sohal, 1992)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

genomic_DNA

(Orr and Sohal, 1992)

wild_type

(Orr and Sohal, 1992)

Mutagen

in vitro construct

(Orr et al., 1996, Sohal et al., 1995, Orr and Sohal, 1992)

Progenitor genotype

Carried in construct

P{Cat7.0}

Cytology

Description

7kb SalI-KpnI genomic fragment containing entire coding region and 1.4kb of upstream sequence.

(Orr and Sohal, 1992)

Allele components

Component

Use(s)

Regulatory region(s)

Cat

Encoded product / tool

Cat

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Orr and Sohal, 1992)

Phenotype Manifest In

Detailed Description

Statement

Reference

Catⁿ¹/Catⁿ⁴ transheterozygote sensitivity to H₂O₂ is considerably attenuated in the presence of a single copy of P{Cat7.0}.

(Orr et al., 1996)

Flies carrying both one copy of Sod^+t2.4 and one copy of Cat^tOa show a retardation in the accumulation of 8-hydroxydeoxyguanosine during aging and in response to exposure to X rays compared to control flies. Age-related loss of Zw activity and increase in the rate of mitochondrial H₂O₂ generation are less steep in flies carrying both one copy of Sod^+t2.4 and one copy of Cat^tOa than in control flies. The metabolic potential, or total amount of oxygen consumed during an average lifespan, is approximately 30% greater in flies carrying both one copy of Sod^+t2.4 and one copy of Cat^tOa than in control flies.

(Sohal et al., 1995)

Overexpression of Cat does not extend the lifespan but does bestow some protection against experimental oxidative stress.

(Orr and Sohal, 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Sod1^+t2.4, Cat^tOa, Trxr1^+t10 is a suppressor of chemical sensitive phenotype of Ppcs¹

(Bosveld et al., 2008)

Sod1^+t2.4, Cat^tOa, Trxr1^+t10 is a suppressor of chemical sensitive phenotype of fbl¹

(Bosveld et al., 2008)

NOT Suppressor of

Statement

Reference

Sod1^+t2.4, Cat^tOa, Trxr1^+t10 is a non-suppressor of abnormal locomotor behavior | adult stage phenotype of Ppcs¹

(Bosveld et al., 2008)

Sod1^+t2.4, Cat^tOa, Trxr1^+t10 is a non-suppressor of radiation sensitive phenotype of Ppcs¹

(Bosveld et al., 2008)

Sod1^+t2.4, Cat^tOa, Trxr1^+t10 is a non-suppressor of abnormal locomotor behavior | adult stage phenotype of Ppat-Dpck⁴³

(Bosveld et al., 2008)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Simultaneous co-expression of Sod^+t2.4, Cat^tOa and Trxr-1^+t10 suppresses the sensitivity of Ppcs¹/Ppcs¹ flies to 5% H[[2]]O[[2]] and 100mM dithiothreitol, and results in increased resistance to 20mM paraquat.

Simultaneous co-expression of Sod^+t2.4, Cat^tOa and Trxr-1^+t10 restores survival of Ppcs¹/Ppcs¹ and fbl¹/fbl¹ larvae on medium containing 100mM cysteine to wild-type levels.

Simultaneous co-expression of Sod^+t2.4, Cat^tOa and Trxr-1^+t10 does not suppress the impaired ability of Ppat-Dpck⁴³ or Ppcs¹ homozygous adults to climb in a negative geotaxis assay.

The reduced survival rate of adults after exposure of larvae to 20Gy irradiation that is seen in Ppcs¹ homozygotes is not rescued by simultaneous co-expression of Sod^+t2.4, Cat^tOa and Trxr-1^+t10.

(Bosveld et al., 2008)

Expression of both Cat^tOa and Sod^+t2.4 does not result in an increase in life span. Co-expression of Cat^tOa, Sod^+t2.4 and Sod2^+t9 does not result in an increase in life span. Expression of both Trxr-1^+t10 and Cat^tOa does not result in an increase in life span.

(Orr et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Cat^tOa

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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