FlyBase Allele Report: Dmel\14-3-3ζ[X1]

General Information

Symbol

Dmel\14-3-3ζ^X1

Species

D. melanogaster

Name

FlyBase ID

FBal0059625

Feature type

allele

Associated gene

Dmel\14-3-3ζ

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Skoulakis and Davis, 1996)

Progenitor genotype

14-3-3ζ^P1375

(Skoulakis and Davis, 1996)

Cytology

Description

Deletion in the intron between exons 1' and 2 of 14-3-3ζ.

(Philip et al., 2001)

Deletion of the P{lArB} insertion and portions of genomic sequence.

(Skoulakis and Davis, 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal learning

(Philip et al., 2001)

abnormal memory

(Philip et al., 2001, Skoulakis and Davis, 1996)

abnormal memory (with 14-3-3ζ^P1375)

(Skoulakis and Davis, 1996)

viable

(Philip et al., 2001, Skoulakis and Davis, 1996)

Phenotype Manifest In

Detailed Description

Statement

Reference

No neuroanatomical aberrations are evident during development of the brain. Flies show reduced performance in a modified olfactory trap assay, using geraniol as the attractive odor, both immediately after training and 90 mins after training.

(Philip et al., 2001)

Exhibits a decrement in the 3 minute memory performance. Transheterozygotes with 14-3-3ζ^P1375 show a highly significant reduction in 3 minute memory. Odour avoidance (octanol and benzaldehyde) is normal.

(Skoulakis and Davis, 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

14-3-3ε^j2B10, 14-3-3ζ^X1/14-3-3zeta[+] has visible | recessive phenotype

(Chang and Rubin, 1997)

14-3-3ε^j2B10, 14-3-3ζ^X1 has visible | dominant phenotype

(Chang and Rubin, 1997)

Phenotype Manifest In

Other

Statement

Reference

14-3-3ε^j2B10, 14-3-3ζ^X1/14-3-3zeta[+] has ommatidium phenotype

(Chang and Rubin, 1997)

14-3-3ε^j2B10, 14-3-3ζ^X1 has eye phenotype

(Chang and Rubin, 1997)

14-3-3ε^j2B10, 14-3-3ζ^X1 has eye photoreceptor cell phenotype

(Chang and Rubin, 1997)

14-3-3ε^j2B10, 14-3-3ζ^X1 has posterior crossvein phenotype

(Chang and Rubin, 1997)

14-3-3ε^j2B10, 14-3-3ζ^X1 has ommatidium phenotype

(Chang and Rubin, 1997)

Additional Comments

Genetic Interactions

Statement

Reference

14-3-3ζ^X1/+ 14-3-3ε^j2B10/14-3-3ε^j2B10 flies have slightly roughened eyes, a low penetrance of missing photoreceptors and a gap in the posterior crossvein of the wings in more than 50% of cases.

(Chang and Rubin, 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

14-3-3ζ^X1 is rescued by 14-3-3ζ^LI.15.hs

(Philip et al., 2001)

14-3-3ζ^X1 is rescued by 14-3-3ζ^LII.2.hs

(Philip et al., 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

14-3-3^X1

14-3-3ζ^X1

leo^X.1

(Chang and Rubin, 1997)

leo^X1

(Philip et al., 2001)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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