FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\14-3-3ζ2.3
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General Information
Symbol
Dmel\14-3-3ζ2.3
Species
D. melanogaster
Name
FlyBase ID
FBal0059634
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
leo2.3
Key Links
Allele class
Nature of the Allele
Allele class
Cytology
Description

Deletion in the intron between exons 1' and 2 of 14-3-3ζ.

Deletion of the P{lArB} insertion and portions of genomic sequence.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

14-3-3ζ2.3 homozygous, but not heterozygous, larvae have significantly reduced amplitude of evoked excitatory junction potentials and a significant increase in the number of incompletely differentiated (ghost) boutons in the neuromuscular junction, compared to controls.

No neuroanatomical aberrations are evident during development of the brain. Flies show reduced performance in a modified olfactory trap assay, using geraniol as the attractive odor, both immediately after training and 90 mins after training.

Exhibits a decrement in the 3 to 240 minute memory performance. Transheterozygotes with 14-3-3ζP1375 show a highly significant reduction in 3 minute memory. Odour avoidance (octanol and benzaldehyde) is normal.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

cindr1/+, 14-3-3ζ2.3/+ double heterozygous larvae have significantly increased numbers of incompletely differentiated (ghost) boutons and significantly reduced amplitude of evoked excitatory junction potentials in the neuromuscular junction, compared to controls.

14-3-3ζ2.3/+ 14-3-3εj2B10/14-3-3εj2B10 flies have slightly roughened eyes, a low penetrance of missing photoreceptors and a gap in the posterior crossvein of the wings in more than 50% of cases.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (5)