FlyBase Allele Report: Dmel\PolZ1[P]

General Information

Symbol

Dmel\PolZ1^P

Species

D. melanogaster

Name

FlyBase ID

FBal0059995

Feature type

allele

Associated gene

Dmel\PolZ1

Associated Insertion(s)

P{}PolZ1^P

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

P-element activity

(Eeken et al., 1997)

MRh12 induced male recombination

(Eeken et al., 2001)

Progenitor genotype

Associated Insertion(s)

P{}PolZ1^P

Cytology

Description

P-element of approximately 2kb is inserted in the first exon. This results in an aberrant transcript that contains an additional intron starting at nucleotide 20 of the P-element and ending 34bp after the P-element in the mus205 sequence, producing a transcript that is 15bp longer than wild type. A stop codon is introduced 9bp after codon 13 of the wild-type product.

(Eeken et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

chemical sensitive

(Eeken et al., 2001)

chemical sensitive | recessive

(Eeken et al., 1997)

viable

(Eeken et al., 2001)

Phenotype Manifest In

Detailed Description

Statement

Reference

Mutant flies are sensitive to methyl methanesulfonate (MMS) compared to wild type, but are not hypersensitive to X rays. In germ cells, no effect on mutability by X-rays, NQO or MMS is seen in mutants. In somatic cells, no effect on MMS-induced mutations or recombinations is seen.

(Eeken et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Separable from: a preexisting mutation in the progenitor stock which results in an increase in the induction of somatic recombination and sex-linked recessive lethals by MMS compared to wild type.

(Eeken et al., 2001)

Comments

A preexisting MMS sensitive mutant (unspecified) is present on the mus205^P chromosome.

(Eeken et al., 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

DNApol-ζ^P

MMS-7

(Eeken et al., 2001)

PolZ1^P

mus205^P

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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