mus205, mutagen-sensitive 205, mus-205, DmREV3
Gene model reviewed during 5.49
There is only one protein coding transcript and one polypeptide associated with this gene
Catalytic subunit of the zeta DNA polymerase complex, which consists of DNApol-zeta/DNApolZ1 and the accessory component Rev7 (PubMed:16507570, PubMed:15175013). Interacts with the apurinic/apyrimidinic (AP) endonuclease Rrp1; the interaction is likely indirect and mediated via Rev7 (PubMed:16507570).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\PolZ1 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\PolZ1 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: mus205 CG1925
Source for merge of mus205 CG1925 was sequence comparison ( date:001108 ).
The mus205 enzyme has a high processivity for DNA synthesis and has a preference for poly(dA)/oligo(dT)<down> 10:1 </down> as a template primer. The activities of bypassing pyrimidine dimers and (6-4) photoproducts and extending from mismatched primer-template termini in (6-4) photoproducts by mus205 have not been detected.
Gene is involved in post-replication translesion synthesis repair.