Multiple DNA polymerases are required for DNA replication in eukaryotic cells. The alpha-primase, delta and epsilon polymerases exist as multi-subunit complexes and are responsible for the bulk of nuclear DNA synthesis. Other specialized polymerases (including eta, iota, theta, zeta and Rev1) are required for nuclear DNA repair and/or translesion DNA synthesis. DNA polymerase gamma is responsible for the replication and repair of mitochondrial DNA. (Adapted from
PMID:30005324.)
