FB2026_02 , released June 18, 2026
Allele: Dmel\kni2FKE.eve
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General Information
Symbol
Dmel\kni2FKE.eve
Species
D. melanogaster
Name
FlyBase ID
FBal0060373
Feature type
allele
Associated gene
Dmel\kni
Associated Insertion(s)
Carried in Construct
P{kni.eve.2FKE}
Key Links
Transgenic product class
cDNA
(Kosman and Small, 1997)
wild_type
(Kosman and Small, 1997)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Kosman and Small, 1997)
wild_type
(Kosman and Small, 1997)
Mutagen
FLPase
(Kosman and Small, 1997)
Progenitor genotype
kniFRT.2FKE.eve
(Kosman and Small, 1997)
Carried in construct
P{kni.eve.2FKE}
Cytology
Description

The Scer\FRT cassette has been excised, juxtaposing eve enhancer and promoter sequences with kni coding sequences.

(Kosman and Small, 1997)
Allele components
Component
Use(s)
Regulatory region(s)
eve
Encoded product / tool
kni
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      More than 75% of mutant embryos die by the end of embryogenesis. Approximately 50% show a complete T2 deletion in dorsal and ventral regions, the phenotype is more severe on the ventral side, with over 90% completely lacking the T2 ventral denticle band.

      (Wu et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      kni2FKE.eve has lethal phenotype, suppressible by hbeve.st2ΔKr

      (Wu et al., 2001)

      kni2FKE.eve has lethal phenotype, suppressible by hbeve.st2

      (Wu et al., 2001)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      When hbeve.st2 is added to kni2FKE.eve animals double the number of survivors are seen. The addition of hbeve.st2ΔKr fully rescues the lethality phenotype.

      (Wu et al., 2001)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Exists in clones, not reported as being germ-line transmitted.

      (Kosman and Small, 1997)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      kni2FKE.eve
      Name Synonyms
      Secondary FlyBase IDs
        References (2)