FlyBase Allele Report: Dmel\eff[tre2]

General Information

Symbol

Dmel\eff^tre2

Species

D. melanogaster

Name

trenino2

FlyBase ID

FBal0060432

Feature type

allele

Associated gene

Dmel\eff

Associated Insertion(s)

P{lacW}eff^tre2

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Cenci et al., 1997)

Progenitor genotype

Associated Insertion(s)

P{lacW}eff^tre2

Cytology

Description

Insertion of P{lacW} between bp 417 and bp 418 (nucleotide positions numbered with respect to male germline 2.1kb transcript).

(Cenci et al., 1997)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:14,740,734..14,740,735 [-]

(Cenci et al., 1997)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal meiotic cell cycle | recessive

(Cenci et al., 1997)

abnormal mitotic cell cycle | recessive

(Cenci et al., 1997)

male sterile | recessive

(Cenci et al., 1997)

partially lethal - majority die | recessive

(Cenci et al., 1997)

Phenotype Manifest In

meiosis & chromosome, telomeric region | male

(Cenci et al., 1997)

meiosis & nuclear chromosome | male

(Cenci et al., 1997)

mitosis & chromosome, telomeric region

(Cenci et al., 1997)

Detailed Description

Statement

Reference

Homozygous larval brain cells contain many telomere-telomere attachments, resulting in a variety of aberrant chromosome configurations. In a few cases, polycentric chromosomes involving most of the genetic complement are seen. Lagging chromatin is seen in anaphase I and anaphase II of male meiosis. Female meiosis appears normal.

(Cenci et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Etymology: eff^tre2 is named 'trenino' (meaning 'little train' in Italian) after the appearance of the multicentric chromosomes seen in larval brain cells.

(Cenci et al., 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

UbcD1^trenino2

(Cenci et al., 1997)

eff^tre2

(Porrazzo et al., 2022)

Name Synonyms

trenino2

(Cenci et al., 1997)

Secondary FlyBase IDs

References (2)

Report Sections

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