FlyBase Allele Report: Dmel\hh[h9D]

General Information

Symbol

Dmel\hh^h9D

Species

D. melanogaster

Name

FlyBase ID

FBal0061378

Feature type

allele

Associated gene

Dmel\hh

Associated Insertion(s)

P{hsp-hh.K}hh^h9D

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Kojima et al., 1994)

Progenitor genotype

hh^hs.PK

(Kojima et al., 1994)

Associated Insertion(s)

P{hsp-hh.K}hh^h9D

Cytology

Description

The P{hsp-hh.K} transgene, carrying hh^hs.PK, is inserted near to an unidentified enhancer at 15A on the X chromosome.

(Kojima et al., 1994)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile

(Kojima et al., 1994)

viable

(Kojima et al., 1994)

visible | semidominant

(Kojima et al., 1994)

Phenotype Manifest In

dorsal row of double row of wing sensilla

(Kojima et al., 1994)

dorsal row of triple row of wing sensilla

(Kojima et al., 1994)

medial row of triple row of wing sensilla

(Kojima et al., 1994)

microchaeta & wing | anterior | proximal

(Kojima et al., 1994)

ventral row of double row of wing sensilla

(Kojima et al., 1994)

ventral row of triple row of wing sensilla

(Kojima et al., 1994)

wing | anterior | proximal

(Kojima et al., 1994)

wing vein L1

(Kojima et al., 1994)

wing vein L2

(Kojima et al., 1994)

Detailed Description

Statement

Reference

Heterozygotes have an outgrowth on the anterior proximal part of the wing. The triple row on the proximal anterior margin is often interrupted by regions with few sensory bristles, and regions of wing vein L1 are often missing. The anterior outgrowth is more extensive in homozygotes and hemizygotes, and wing vein L2 is bifurcated. In addition, trichomes in the anterior proximal half of the wing are oriented abnormally, turning towards the anterior-most and/or proximal margins. Trichomes in the distal half of the wing are oriented normally. The interruptions in the triple row on the proximal anterior margin often contain no sensory or proximal row bristles in homozygotes or hemizygotes. There is frequently a stretch of double row bristles replacing the triple row bristles immediately adjacent to this region. Costal structures are often missing. The posterior compartment of the wing appears normal. These phenotypes suggest that hh^h9D causes abnormal outgrowth in the anterior of the wing, together with a partial mirror-image duplication of the anterior structures.

(Kojima et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

hh^h9D has wing | anterior | proximal phenotype, enhanceable by ptc⁹

(Kojima et al., 1994)

hh^h9D has dorsal row of triple row of wing sensilla phenotype, enhanceable by ptc⁹

(Kojima et al., 1994)

hh^h9D has medial row of triple row of wing sensilla phenotype, enhanceable by ptc⁹

(Kojima et al., 1994)

hh^h9D has ventral row of triple row of wing sensilla phenotype, enhanceable by ptc⁹

(Kojima et al., 1994)

hh^h9D has wing | anterior | proximal phenotype, enhanceable by ptc⁵

(Kojima et al., 1994)

Additional Comments

Genetic Interactions

Statement

Reference

The hh^h9D phenotype is enhanced by reducing the number of copies of ptc⁺; in hh^h9D ptc⁹ or hh^h9D ptc⁵ double heterozygotes, the area surrounded by the bifurcated wing vein L2 is reduced in size compared to hh^h9D single heterozygotes, and a new-vein like structure appears in the anterior proximal region. In hh^h9D homozygotes or hemizygotes that are also heterozygous for ptc⁹, triple row bristles are restricted to the area on the margin where the plexated vein L2 terminates. The vein-like structure in the anterior proximal region is broader than in hh^h9D ptc⁹ or hh^h9D ptc⁵ double heterozygotes, and is associated with campaniform sensilla, a characteristic of wing vein L3.

(Kojima et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

h9^D

(Kojima et al., 1994)

hh^h9D

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

Open Close